대한소아신장학회  14 권  2 호 년 2010 □ 원 저 □ DOI 10.3339/jkspn.2010.14.2.166 1) * 현 경훈 두 저자는  연구에 동일하게 기여하였음 , . *  논은 대한소아신장학회 년 회 페링연구 원으로 이루어음 2006 9 . 접수 : 년 월 일 수 2010 9 20 , : 년 월 일 승인 2010 10 4 , : 년 월 일 2010 10 9 임저자 : 하일수 서울시 로구 연건동  서울대학교 어린이원 소아소년과 , 28 Tel : 02)2072-2858 Fax : 02)2072-0274 E-mail : ilsooha@snu.ac.kr 소아 복막투석환자에서 혈관내피성장인자 유전자 다형성이 복막의 용질이동성에 미치는 영향 서울대학교 의과대학 예의학교실 성균관대학교 의과대학 삼성서울원 소아소년과 , * 관리 예접관리과 † 서울대학교 어린이원 소아소년과 , ‡ 인대학교 해운대 원 소아소년과 § 최현진 백경훈 ㆍ * 조희연 ㆍ † 강희경 ㆍ ‡ 정해일 ㆍ ‡ 최용 ㆍ § 하일수 ㆍ ‡ = Abstract = Influence of VEGF Genetic Polymorphism on Peritoneal Solute Transport in Pediatric Dialysis Patients Hyun Jin Choi, M.D., Kyung Hoon Paik, M.D. * Hee Yeon Cho, M.D. † , Hee Kyung Kang, M.D. ‡ Hae Il Cheong, M.D. ‡ , Yong Choi, M.D. § and Il Soo Ha, M.D. ‡ Department of Preventive Medicine, College of Medicine, Seoul National University Department of Pediatrics * , Samsung Medical Center, Sungkyunkwan University School of Medicine Division of Vaccine Preventable Disease Control and National Immunization Program † Korean Centers for Disease Control and Prevention Department of Pediatrics ‡ , Seoul National University Children s Hospital ’ Department of Pediatrics § , Inje University Haeundae Paik Hospital Purpose : Genetic and clinical factors can influence the permeability of the peritoneal mem- brane. The peritoneal equilibration test (PET) is helpful in measuring peritoneal permeability in peritoneal dialysis (PD). We investigated the influence of genetic polymorphism of vas- cular endothelial growth factor (VEGF) on the PET parameters. Methods : Pediatric patients who underwent PET within 12 months of initiating PD at Seoul National University Children s Hospital and Samsung Medical Center were selected. The ’ patients with positive history of peritonitis before PET were excluded. The VEGF -2578C/ A, -14978T/C, -1154G/A, -634G/C, and +936C/T single-nucleotide polymorphisms were genotyped. Results : The mean 4-hour dialysate-to-plasma ratio for creatinine (D/P creatinine) and the mean 4-hour dialysate glucose to baseline dialysate glucose ratio (D/D0 glucose) were 0.56 0.13 and 0.43 0.11, respectively. The patients with haplotype CTGGC showed higher ± ± 4-hour D/P creatinine (0.67 0.12 vs 0.50 0.09, ± ± P =0.007) and lower 4-hour D/D0 glucose (0.35 0.12 vs 0.47 0.08, ± ± P =0.037) than those without haplotype CTGGC. Conclusion : The VEGF genetic polymorphism may influence the peritoneal solute tran- sport. (J Korean Soc Pediatr Nephrol 2010;14:166-173)