Accepted Manuscript New 1,2,4-triazole-Chalcone hybrids induce Caspase-3 dependent apoptosis in A549 human lung adenocarcinoma cells Fatma F. Ahmed, Amer Ali Abd El-Hafeez, Samar H. Abbas, Dalia Abdelhamid, Mohamed Abdel-Aziz PII: S0223-5234(18)30316-7 DOI: 10.1016/j.ejmech.2018.03.073 Reference: EJMECH 10338 To appear in: European Journal of Medicinal Chemistry Received Date: 13 September 2017 Revised Date: 23 March 2018 Accepted Date: 24 March 2018 Please cite this article as: F.F. Ahmed, A.A. Abd El-Hafeez, S.H. Abbas, D. Abdelhamid, M. Abdel-Aziz, New 1,2,4-triazole-Chalcone hybrids induce Caspase-3 dependent apoptosis in A549 human lung adenocarcinoma cells, European Journal of Medicinal Chemistry (2018), doi: 10.1016/ j.ejmech.2018.03.073. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.