BACKGROUND Chronic illness affects not only the patient, but also the caregiver's family, increasing the caregiver's burden. Chronic kidney failure is a condition that typi- cally requires hemodialysis. The family, as the patient's closest friends, shares responsibility for the treatment. CAREGIVER'S BURDEN AMONG FAMILIES OF HEMODIALYSIS PATIENT: A CROSS-SEC- TIONAL STUDY Novita Nirmalasari 1 *, Ike Wuri Winahyu Sari 2 1,2 Faculty of Health, Universitas Jenderal Achmad Yani Yogyakarta ABSTRACT The end-stage renal disease affects almost every aspect of the pa- tients' and caregivers' lives. Several studies have been conducted to explore the experiences of family caregivers in caring for hemodialy- sis patients. However, a survey of the burden of family caregivers has yet to be conducted in Indonesia, a country with strong family bonds among family members. This study aimed to identify the bur- den among family caregivers of hemodialysis patients.This study was a cross-sectional study conducted in May 2021 on 60 family caregivers of hemodialysis patients. selected using a purposive sampling tech- nique. Semi structured questionnaires were used to measure socio- demographic. The Caregiver Reaction Assessment-Indonesian Ver- sion (CRA-ID) was used to measure their burden. Data were ana- lyzed using descriptive analyzes and bivariate analyzes. Women rep- resented 65% (n=39) of participants, married participants were 83.3% (n=50), and were 63.3% employed (n=38). Most of them have mini- mum family income (51.7%). The least common association of caregivers was the spouses of the patients (n=32, 53.3%). The analysis showed that the mean overall burden score with CRA-ID was 2.88 0.69 (ranging 1.00 to 5.00). The highest burden was the lack of fam- ily support dimension of 3.47 0.42. Caregiver burden among caregivers of patients on hemodialysis showed that the variables related to fam- ily burden were age, an education level, and family income (p- value<0,05). Caregivers of hemodialysis patients carry a significant burden. Interventions to provide appropriate social support to patients and increase caregivers' psychological conditions are critical. Keywords: Burden, Caregivers, Chronic illness, Hemodialysis NurseLine Journal Volume 7, Issue 1, May 2022 p-ISSN: 2540-7937 e-ISSN: 2541-464X *Corresponding Author: Novita Nirmalasari Faculty of Health, Universitas Jenderal Achmad Yani Yogyakarta novitanirmalasari@gmail.com Article Info: Submitted: 2022-01-05 Reviewed: 2022-03-23 Revised: 2022-04-11 Accepted: 2022-04-26 Chronic illness in one family member is a source of concern for the entire family because of the eco- nomic and psychosocial consequences, as well as the impact on lifestyle (Kilic & Kaptanogullari, 2017). Family caregivers play an important role in the care of hemodialysis patients. Although caring for a fam- ily member is a rewarding experience, the physical