American Journal of Analytical Chemistry, 2021, 12, 446-457 https://www.scirp.org/journal/ajac ISSN Online: 2156-8278 ISSN Print: 2156-8251 DOI: 10.4236/ajac.2021.1211028 Nov. 30, 2021 446 American Journal of Analytical Chemistry Controlling the Shape, Pore Size and Surface Area of Prepared Mesoporous Silica Particles by Altering the Molar Concentration of Tetramethoxysilane Mohammed M. Algaradah Department of Chemistry, King Khalid Military Academy, Riyadh, Kingdom of Saudi Arabia Abstract In recent days, the applications of silica-based nanoparticles have gained much attention. The preparation of mesoporous silicas is usually achieved via the modified Stöber method, the reaction attained by the hydrolysis and con- densation of silica precursors present within a medium containing template, solvent, deionized water (DI-W) and base. Therefore, the current study aimed to prepare and characterize mesoporous silicas by using tetramethoxysilane (TMOS) as silica precursor and ethylene glycol (Et-G) as solvent. The study was based on the template dodecyltrimethylammonium bromide (C 12 TMABr) and sodium hydroxide used as an alkaline agent. Mesoporous silicas were prepared in various batches based on TMOS molar concentration, ionized wa- ter, NaOH, and other solvents. The characterization of mesoporous silicas was achieved based on their specific surface area, pore size distribution and morphology using different instruments: Brunauer, Emmett & Teller (BET), scanning electron microscopy (SEM), Fourier-transform infrared spectros- copy (FT-IR), and thermalgravimetric analysis (TGA). The study revealed that shape, average particle sizes “35 to 550 nm”, average pore radius “1.62 - 4.5 nm” and surface area “350 - 1204 m 2 ∙g −1 ” of obtained mesoporous silica par- ticles were altered based on precursor concentration and other factors. There- fore, it is important to get the most suitable concentration of all chemicals in the preparation of mesoporous silicas to control the particle characteristics to use them upon their further applications. This is the baseline study that pro- vides details regarding prepared silica particles with controlled characteris- tics, and more studies related to its applications are still in process. How to cite this paper: Algaradah, M.M. (2021) Controlling the Shape, Pore Size and Surface Area of Prepared Mesoporous Silica Particles by Altering the Molar Concentra- tion of Tetramethoxysilane. American Jour- nal of Analytical Chemistry, 12, 446-457. https://doi.org/10.4236/ajac.2021.1211028 Received: October 25, 2021 Accepted: November 27, 2021 Published: November 30, 2021 Copyright © 2021 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access