https://dx.doi.org/10.4314/dujopas.v8i2b.19 ISSN (Print): 2476-8316 ISSN (Online): 2635-3490 Dutse Journal of Pure and Applied Sciences (DUJOPAS), Vol. 8 No. 2b June 2022 *Author for Correspondence J. J. Kalang et al, DUJOPAS 8 (2b): 191-203, 2022 191 Influence of Hydrocortisone, Dexamethasone and Methylprednisolone on Wound Healing Parameters on Nigerian Indigenous Dogs Japheth Joel Kalang 1 , Hassan Adamu Zoaka 2 , Fatihu, M. Y 3 , Markus Isa Francis 4 , Adaji Ocholi Gideon 1 , Polycarp Nwunuji Tanko 5 1 Department of Veterinary Medicine, Surgery and Radiology, University of Jos, Nigeria 2 Department of Veterinary Surgery and Radiology, Ahmadu Bello University Zaria, Nigeria 3 Department of Veterinary Pathology, Ahmadu Bello University Zaria, Nigeria 4 Department of Veterinary clinical services, Ministry of livestock and Aquaculture Yola, Adamawa State Nigeria 5 Department of Veterinary Microbiology and Pathology, University of Jos, Nigeria Email: japhethjkalang@gmail.com Abstract Wound healing is a complex activity of several cells with their products leading to tissue regeneration and repair. Twelve indigenous breeds of dogs were randomly grouped into groups I, II, III and IV of 3 dogs each. Excisional and incisional wounds were surgically created on the left and right sides respectively. The dogs in Group I were administered normal saline while Groups II, III and IV were given hydrocortisone, dexamethasone and methylprednisolone respectively at 1.0, 0.5 and 1.0 mg/kg intramuscularly post-wounding. The wounds were cleaned and assessed for epthelialisation, contraction and pus formation. RESULT: The wound dimensions from insult of excisional wound, increased steadily to peak (10.34 cm 2 ) at 10 th day in the control, (12.21 cm 2 ) 17 th day; (11.97 cm 2 ) 12 th day and (13.87 cm 2 ) 17 th day post-wounding in the hydrocortisone, dexamethasone and methylprednisolone treated groups respectively. Maximum contraction was recorded at 33 rd day (3.52 cm 2 ) in the control, 40 th days (3.55 cm 2 ), 30 th (3.86 cm 2 ) and 42 nd (3.98 cm 2 ) in the hydrocortisone, dexamethasone and methylprednisolone groups respectively with insignificant statistical difference.