Available online at www.sciencedirect.com Food and Bioproducts Processing journal homepage: www.elsevier.com/locate/fbp Prototypes of nutraceutical products from microparticles loaded with stilbenes extracted from grape cane Javier Avendaño-Godoy a , Elisa Ortega a , Manuel Urrutia a , Danilo Escobar-Avello c,d , Javiana Luengo a , Dietrich von Baer b , Claudia Mardones b , Carolina Gómez-Gaete a, ⁎ a Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile b Departamento de Análisis Instrumental, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile c Unidad de Desarrollo Tecnológico, Universidad de Concepción, Coronel, Chile d Centro Nacional de Excelencia para la Industria de la Madera (CENAMAD), Pontifcia Universidad Católica de Chile, Santiago, Chile a r t i c l e info Article history: Received 9 January 2022 Received in revised form 8 April 2022 Accepted 25 April 2022 Available online 30 April 2022 Keywords: Grape cane Vitis vinifera Stilbenes Microencapsulation Spray-drying Nutraceutical abstract Grape canes (Vitis vinifera L.) are an important source of bioactive stilbenes, but they are considered a pruning residue. Despite the potential advantages for human health, the low aqueous solubility and stability limits their usage in commercial goods. This research aimed to improve knowledge about the solubility and stability of the main stilbenes present in important residues of the wine industry, such as grape canes (V. vinifera L. cv. Pinot Noir), through the formation of inclusion complexes with cyclodextrins (CDs) and subsequent polymeric microencapsulation. The formation of inclusion complexes between stilbenes presents in grape cane ex- tracts and 15 mM hydroxypropyl-β-cyclodextrin (HP-β-CD) increased the aqueous solubi- lity of (E)-resveratrol, (E)-ɛ-viniferin and (E)-piceatannol by 2.8, 5.4 and 1.9 times, respectively. The microencapsulation (by spray drying) of the inclusion complexes using maltodextrin (MD) (10% w/v) allowed us to improve the stability of the stilbenes, obtaining a retention percentage of 81.9 ± 2.2% after 60 min of UV irradiation (254 nm). The lower size microparticles (MPs) formulation was 10.9 ± 0.9 µm and had a stilbene loading of 0.61 ± 0.01 mg/100 mg of MPs. The prototype tablets and capsules made from the MPs presented suitable characteristics for their eventual use. The microencapsulation of inclusion complexes between stilbenes presents in grape cane extracts and HP-β-CD, using MD as a matrix component, is useful to increase the solubility and stability of stilbenes. The prepared MPs can be used for the development of nutraceutical products. © 2022 Institution of Chemical Engineers. Published by Elsevier Ltd. All rights reserved. 1. Introduction Stilbenes correspond to non-favonoid phenolic compounds that are produced by the secondary metabolites of plants. They play an important role in their defense mechanism, against biotic and abiotic stress. Members of the stilbene fa- milies possess a carbon skeleton based on the (E)-resveratrol https://doi.org/10.1016/j.fbp.2022.04.007 0960-3085/© 2022 Institution of Chemical Engineers. Published by Elsevier Ltd. All rights reserved. ]] ]] ]]]]]] ⁎ Corresponding author. E-mail address: cargomez@udec.cl (C. Gómez-Gaete). Food and Bioproducts Processing 134 (2022) 19–29