Accepted Manuscript Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17α-hydroxylase-C17,20-lyase (Cyp17) Benjamin E Blass, Pravin Iyer, Magid Abou-Gharbia, Wayne E Childers, John C Gordon, Mercy Ramanjulu, George Morton, Premkumar Arumugam, Joshodeep Boruwa, John Ellingboe, Sayan Mitra, Rajashekar Reddy Nimmareddy, Shalini Paliwal, Jamallamudi Rajasekhar, Savithiri Shivakumar, Pratima Srivastava, Raghuram S. Tangirala, Konda Venkataramanaiah, Ramreddy Bobbala, Mahesh Yanamandra, L. Krishnakanth Reddy PII: S0960-894X(18)30441-4 DOI: https://doi.org/10.1016/j.bmcl.2018.05.040 Reference: BMCL 25857 To appear in: Bioorganic & Medicinal Chemistry Letters Received Date: 30 January 2018 Revised Date: 17 May 2018 Accepted Date: 18 May 2018 Please cite this article as: Blass, B.E., Iyer, P., Abou-Gharbia, M., Childers, W.E., Gordon, J.C., Ramanjulu, M., Morton, G., Arumugam, P., Boruwa, J., Ellingboe, J., Mitra, S., Nimmareddy, R.R., Paliwal, S., Rajasekhar, J., Shivakumar, S., Srivastava, P., Tangirala, R.S., Venkataramanaiah, K., Bobbala, R., Yanamandra, M., Reddy, L.K., Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17α-hydroxylase-C17,20-lyase (Cyp17), Bioorganic & Medicinal Chemistry Letters (2018), doi: https://doi.org/10.1016/j.bmcl.2018.05.040 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.