Journal Pre-proof Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors Cun-Jian Shi, Wan Peng, Jin-Hua Zhao, Hua-Li Yang, Lai-Liang Qu, Cheng Wang, Ling-Yi Kong, Xiao-Bing Wang PII: S0223-5234(19)31113-4 DOI: https://doi.org/10.1016/j.ejmech.2019.111961 Reference: EJMECH 111961 To appear in: European Journal of Medicinal Chemistry Received Date: 21 November 2019 Revised Date: 9 December 2019 Accepted Date: 9 December 2019 Please cite this article as: C.-J. Shi, W. Peng, J.-H. Zhao, H.-L. Yang, L.-L. Qu, C. Wang, L.-Y. Kong, X.- B. Wang, Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors, European Journal of Medicinal Chemistry (2020), doi: https://doi.org/10.1016/j.ejmech.2019.111961. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2019 Published by Elsevier Masson SAS.