Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. Abstracts e521 two final datasets, control profile and case profile, encompassing 189 normotensive placentas and 138 PE samples, respectively. Using weighted gene co-expression net- work analysis (WGCNA), we identified modules of co-expressed genes distinguish- ing normal placentas from PE conditions. Pathway analysis of these modules was carried out to highlight pathways that may be involved in the development of PE. Results: Using WGCNA, we identified six lowly preserved modules between normal placentas and PE conditions. These modules are mainly related to MAPK signaling pathway, VEGF signaling pathway, Jak-STAT signaling pathway, Tight junction, Gap junction, focal adhesion, Regulation of actin cytoskeleton, Fatty acid elongation in mitochondria, Aminoacyl-tRNA biosynthesis, Cell cycle and Spliceosome. Conclusions: Using this pool and systems biology approach, we identified several gene modules which may play roles in the PE conditions. [Table 1.KEGG analysis of hub genes in the lowly preserved modules between normal placentas and PE conditions.] [Figure 1. Clustering dendrograms and modules identified by weighted gene co-expres- sion network analysis (WGCNA). In the upper panel, the clustering diagram and 42 modules for normal dataset are shown.] LBPS 02-56 RELATION BETWEEN OBESITY AND HYPERTENSION IN FEMALE; CASE STUDY OF SETIABUDI COMMUNITY HEALTH CENTER, SOUTH JAKARTA, INDONESIA Lindawati Amsir Saidi 1 , Lindrianasari Amsir Saidi 2 . 1Community Health Cen- tre, General Practitioner, Indonesia, 2Universitas Lampung, Lecturer, Indonesia Objective: The study aims to identify tendency of hypertension in human being. Design and Method: The focus of the analysis is age and body mass index in patients at community health center of Setia Budi, South Jakarta. The amount of population in the study is 744 male and female hypertension patients. Data were collected randomly for 20 months in June 2014 until January 2016 from hypertension case at health center. Results: The results of this study are found that female patients who suffer hy- pertension have higher body mass index compared to male patients. Meanwhile, hypertension is not affected by age. This means that people can suffer hyperten- sion even though they are young. Conclusions: This study concludes that women should be more careful about their weight because excess body weight has a high potential to cause hyperten- sion in women. As for men, while the weight of the body is not the main factor, another factor related lifestyle may be the trigger factor of hypertension. About this, we have suggested to do the research. LBPS 02-57 HYPERTENSION IN DENGUE PATIENTS: IMPORTANT CONCERN Viroj Wiwanitkit. Department of Public Health, Surin Rajabhat University, Su- rin, Thailand, Thailand Objective: Dengue is a common important arboviral disease. This infection can cause severe illness including hemorrhage, hypotension and shock. The objective of this work is to determine the rate of hypertension among the dengue patients at the first visit. Design and Method: A retrospective review of medical record of dengue patients at the first visit is done. The record of vital sign was assed to find numbers of cases with hypertension. Results: According to the review of medical record of 325 dengue patients at the first visit, there are 85 cases with hypertension (26.15 %). Conclusions: The observed high rate of hypertension among dengue patients at the first visit implies that the determination of blood pressure for predicting severe infection might not be clinically reliable. LBPS 02-58 EFFECTIVITY OF HYPERBARIC OXYGEN THERAPY ON LOWERING SYSTOLIC BLOOD PRESSURE AND HEART RATE AMONG NAVAL DIVERS Benny Minthara. Department of Hyperbaric Medicine, Dr. Ramelan Naval Hos- pital, Surabaya - Indonesia, Indonesia Objective: Given the strong selective constraints stemming from low oxygen level in the blood, divers of the Indonesian naval uniquely adapted to their hypoxemic in terms of systemic vasculature. Vascular endothelial nitric oxide (NO) impairment can increase peripheral vascular resistance, leads to high blood pressure. In the previous study, the effectiveness of hyperbaric oxygen therapy (HBO 2 T) on selected divers suffering hyper- tension remains controversial. Hereby, the aim of this study was to assess the usefulness of HBO 2 T in the secondary prevention of hypertension among naval divers. Design and Method: 72 consecutive naval divers with hypertension (JNC 8 criteria) who met the inclusion criteria were entered in this randomized controlled clinical trial. The patients were randomized into two groups, as follows: 1) experimental: received 2.5 ATA hyperbaric chambers with 96% oxygen supply via oxygen hoods + standard treatment (Amlodipine 10 mg), 2) control: received only standard treatment (Amlodipine 10 mg). The systolic BP (SBP), diastolic BP (DBP), and heart rate (HR) were measured before each HBO 2 T session every 2 weeks until 1-year follow-up. Results: Before the first treatment session with HBO 2 T, the average SBP, DBP, and HR were similar in both groups. The average HR was significantly lower in experimental groups after at least 2-months treatment duration (p-value = 0.01). The average SBP was significantly lower in experimental groups after at least 3-months treatment duration (p-value = 0.04). No significant difference of DBP were detected in both groups until 1-year follow up (p-value = 0.36). Conclusions: Cold water and hydrostatic pressure from water immersion can in- crease blood pressure among naval divers, while HBO 2 T can reduce blood pres- sure significantly. This is a pilot study for effectiveness of HBO 2 T in hyperten- sion; need to be caution in interpreted. LBPS 02-59 GENETIC POLYMORPHISMS ASSOCIATED WITH THE DEVELOPMENT OF COMORBIDITY OF ESSENTIAL HYPERTENSION AND TYPE 2 DIABETES IN UKRAINIAN POPULATION Anna Shalimova 1 , Olexander Bilovol 2 , Lesya Bobronnikova 2 , Kostyantyn Pro- solenko 3 . 1 Department of Therapy and Nephrology, Kharkiv Medical Academy