Research article International Journal of Heterocyclic Chemistry, Vol. 7, No. 1, pp. 1-70 (Winter 2017) © Islamic Azad University, Ahvaz Branch http://ijhc.iauahvaz.ac.ir Reaction of benzoylpyruvate with a mixture of aromatic aldehydes and 5-amino-1,3,4-thiadizole-2- thiol Neda Tavakkoli*, Hassan Kabirifard Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran *Corresponding author: E-mail: Neda_tavakoli1366@yahoo.com Abstract Reactions of benzoylpyruvate with a mixture of aromatic aldehydes and 5- amino-1,3,4-thiadizole-2-thiol in a 1:1:1 molar ratio, afforded 5-(5-aryl-4- benzoyl-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-1,3,4-thiadizole-2-thiols (3a-c). The structure of the resulted products was confirmed by determination of the melting point and spectrophotometric techniques such as IR and 1H- NMR spectroscopy. Keywords: Benzoylpyruvate; Aromatic aldehydes; 5-amino-1,3,4- thiadizole-2-thiol; Multi-component reactions (MCRs); Introduction N-Substituted 4-acyl-5-aryl-3-hydroxy-3-pyrrolin-2-ones have been synthesized via reactions of acylpyruvic acid esters with a mixture of aromatic aldehyde and amine [1-6].