DOI: https://doi.org/10.53350/pjmhs2115123156 ORIGINAL ARTICLE 3156 P J M H S Vol. 15, No.12, DEC 2021 Evaluation of Serum Lipid Profile in Type II Diabetes Patients at Mirpur Khas, Sindh, Pakistan PIR ABDUL HAYEE 1 , KHALIL AHMED MEMON 2 , ATTAULLAH 3 , MOHAMMAD AKBER HASSAN 4 , SHAFAQ ANSARI 5 , HABIB-UR- REHMAN CHOHAN 6 , KARISHMA KUMARI 7 , MARVI 8 , ABDUL SAMAD 9 1 Assistant Professor, Department of Medicine, Muhammad Medical College, Mirpurkhas, Sindh, Pakistan 2 Lecturer, Department of Pathology, Liaquat University of Medical Health Sciences, Jamshoro, Sindh, Pakistan 3 Senior Lecturer, Department of Community Medicine, Mekran Medical College Turbat, Baluchistan 4 Associate Professor, Department of Pathology, Baqai Medical University, Karachi, Sindh, Pakistan 5 Assistant Professor, 6 Associate Professors, Department of Physiology, Muhammad Medical College, Mirpurkhas, Sindh, Pakistan 7 Final Year MBBS Student, Dow Medical College, DUHS Karachi 8 Assistant Professor, Department of Pharmacology, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta 9 Assistant Professor, Department of Forensic Medicine& Toxicology, PUMHSW, Nawabshah, District (SBA), Sindh, Pakistan Correspondence to Dr. Pir Abdul Hayee, Cell: 0335-2831238, Email: drpirabdulhayee@yahoo.com ABSTRACT Aim: To assess the serum cholesterol levels of the diabetes patients in the rural areas of the Sindh. Study design: Prospective observational study Place and duration of study: Department of Medicine, Muhammad Medical College Hospital, Mirpurkhas Sindh, Pakistan from 1 st January 2020 to 31 st December 2020. Methodology: Five hundred and seventeen diabetic type II patients were enrolled in the study after the written informed consent. The serum lipid profile was assessed and analyzed the relation with glycemic values and their treatment. The prescription was also assessed and data were transferred in to data analysis sheet. Results: There were 368 (71.18%) males and 149 (28.82%) females. Moreover 223(43.13%) patients were aged from 51 to 60 years. Patients had 3 to 6 years of diabetic history (51.26%). Patients had glycemic value 151-200mg/dL (33.27%). One hundred and eighty nine patients had total cholesterol value 201-250 mg/dL. One hundred and seventy six patients were prescribed from Sulphonylurea with 34.04%, 205 patients were prescribed lovastatin (39.65%), 97 patients were prescribed rosuvastatin Conclusion: The changes in the lipid profile levels of diabetic patients might occur at different ages along with the morbid condition such as diabetes mellitus and condition can be more complicated if not managed properly. The disruption in the serum lipid profile, total cholesterol, triglycerides, LDL, HDL and obesity cannot be ignored the condition is worse in developing countries like Pakistan. Keywords: Lipid, Diabetes Mellitus, Mirpurkhas, Sindh, Pakistan INTRODUCTION Diabetes mellitus (DM) is a chronic disease that is characterized by the metabolic disorder. The diabetes mellitus involves the various other complications. 1 Diabetes mellitus is not an epidemic but it has turned out as the pandemic in the undeveloped countries 2 . The insulin malfunction disabled the production cells that produces the insulin, in response to that the high amount of blood glucose is found in the blood. The High blood glucose levels are known as diabetes mellitus. The disease of high blood glucose levels involves the multiple complications 3 . Most cases of high glucose levels are linked with dyslipidemia, gender-based diabetes effects the patients with cholesterol levels 4 . The type II diabetes mellitus is characterized by the in- sufficient insulin in the body which normally occurs in the adult ages. The numbers of effected people with diabetes increase with every year, according to an estimation the diabetes patients increased from 19 million to the 40 million within 10 years, however the number is projected to increase till 69.9 million by the year 2025. 5 The type II DM not only effect the insulin and pancreatic activities, but also disturbs the other organ of the body, hence causing the various co morbidities. The changes in the lipid profile levels of diabetic patients occur in different ages of diabetes people and affect the patients with multiple complications. 6 The alteration in the serum lipid profile, total cholesterol, triglycerides, LDL, HDL and obesity cannot be ignored. The high cholesterol levels have the evident risks to develop the coronary artery diseases. The increase in the serum cholesterol levels rises of risks of heart problems, cardiovascular disease and the coronary heart diseases. 7 Although the relationship between has not been researched much, yet the few researchers have worked on the similar issues. The diabetes mellitus patients need to assess their serum levels to reduce the chances of heart problems. The lipid profile is mandatory to be ----------------------------------------------------------------------------------------- Received on 24-06-2021 Accepted on 13-11-2021 assessed with the blood glucose levels. 8 Type II DM is clearly associated with the serum profile of the patients, and cluster of plasma lipids levels, the abnormalities of lipoprotein. The abnormalities of HDL and LDL are predominance. 9 The pre- diabetic often exhibits the altered pattern of serum levels, and higher cholesterol levels lower levels of HDL cholesterol than the non-diabetic. 10 The reduction in the HDL and serum lipid profile is a multi-factorial part, where the resistance in the insulin is linked with the lipoprotein and reciprocal profile of lipids in the serum. The triglycerides and LDL are the most likely to be linked with impaired glucose levels of the body. 11 The objective of the study was to assess the serum cholesterol levels of the diabetes patients in the rural areas of the Sindh. MATERIALS AND METHODS A prospective observational study was conducted at Muhammad Medical College Hospital, Mirpurkhas, Sindh, Pakistan from January 2020 to December 2020 after approval from IRB. A total of 517 diabetic type II patients were enrolled in the study after the written informed consent. The place of study was selected on the basis of flow of diabetic patients. The patients were enrolled from the diabetic out-patient department. The serum lipid profile was assessed and analyzed the relation with glycemic values and their treatment. The prescription was also assessed and data were transferred in to data analysis sheet. The analysis sheet contains gender, age, locality, history, glycemic values, medicines prescribed and serum lipid profile. The data were assessed descriptively by using Microsoft excel and SPSS version 20. RESULTS There were 368(71.18%) male patients and 149(28.82%) female patients. One hundred and one (19.54%) patients were aged from 41 to 50 years, 223(43.13%) patients were aged from 51 to 60 years, 129(24.95%) patients were aged from 61 to 70 years and 64 (12.38%) patients were aged more than 70 years. One hundred and eighty two (35.20%) patients had 1 to 3 years of diabetic history, 265 (51.26%) patients had 3 to 6 years of diabetic history,