S1 Concise solid-phase synthesis of inverse poly(amidoamine) dendrons using AB 2 building blocks Adela Ya-Ting Huang, a Ching-Hua Tsai, a Hsing-Yin Chen, a Hui-Ting Chen, b Chi-Yu Lu, c Yu-Ting Lin, a Chai-Lin Kao a * a Department of Medicinal and Applied Chemistry b Department of Fragrance and Cosmetic Science, c Department of Biochemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan clkao@kmu.edu.tw Synthesis and Characterization To the solution of 3-bromopropylamine hydrobromide (2.0 g, 9.13 mmole) in CH 2 Cl 2 (30 mL) was added triethylamine (4.1 g, 36.52 mmole, 4 eq) and stirred at rt for 30 min. To the resulting solution was added di-tert-butyl-dicarbonate (2.42 g, 10.96 mmole, 1.2 eq) and stirred at rt under N 2 for 12 hours. The resulting mixture was partitioned between ethyl acetate and H 2 O. The organic layer was washed with brine and concentrated in vacuo to give an oily mixture which was further purified by column chromatography (eluent: ethyl acetate: hexane=1:5) to give a colorless oil as product (2.13 g, 98 %, Rf = 0.5; eluent: ethyl acetate: hexane = 1:3). 1 H NMR (400 MHz，CDCl 3 ) δ 1.43 (s, 9H), δ 2.04 (tt, J = 6.2, 6.4 Hz, 2H), δ 3.26 (br, 2H), δ 3.43 (t, J = 6.4 Hz, 2H), 4.67 (brs, 1H); 13 H NMR (400 MHz，CDCl 3 ) δ 27.1, 28.2, 30.8, 32.9, 39.1, 156.1; HRMS (FAB) calcd for C 8 H 16 BrNO 2 [M + ] 237.0364, found 237.0360. 0.5 0.5 1.0 1.0 1.5 1.5 2.0 2.0 2.5 2.5 3.0 3.0 3.5 3.5 4.0 4.0 4.5 4.5 5.0 5.0 5.5 5.5 6.0 6.0 Br NHBoc 5 Electronic Supplementary Material (ESI) for Chemical Communications This journal is © The Royal Society of Chemistry 2013