Int. J. Pharm. Sci. Rev. Res., 74(2), May - June 2022; Article No. 02, Pages: 9-22 ISSN 0976 – 044X International Journal of Pharmaceutical Sciences Review and Research Available online at www.globalresearchonline.net ©Copyright protected. Unauthorised republication, reproduction, distribution, dissemination and copying of this document in whole or in part is strictly prohibited. 9 C. J Patil * , Sanjiv B. Salve Organic Research Laboratory, Department of Chemistry, Smt. G. G. Khadse College, Muktainagar-425 306, Dist. Jalgaon, M.S., India. *Corresponding author’s E-mail: drcjpatil@yahoo.com Received: 09-12-2021; Revised: 15-05-2022; Accepted: 23-05-2022; Published on: 15-06-2022. ABSTRACT Schiff base and its complexes with catalytic activity have rich diversity and the reactions catalysed by these catalyst were reviewed. These complexes are of salen type and some are of other (Salophen and Salcyclo etc.). Here we have the salen and salcyclo types of the complexes. The varied synthetic ligands are available for asymmetric catalysis. They have been highly enantioselective and of synthetic utility for transformation by catalytic behavior. Their catalysis involves many types of organic reactions such as Diels Alder, Aldol, Epoxidation, Polymerization and many more. In addition, they have exciting therapeutic activity. Literature shows very few oxidation reactions of benzyl alcohol and alkanol types of the compound. Keywords: Chiral Schiff bases, Complexes, Salophen and Salcyclo, Catalysis, Oxidation, organic reactions. QUICK RESPONSE CODE → DOI: 10.47583/ijpsrr.2022.v74i02.002 DOI link: http://dx.doi.org/10.47583/ijpsrr.2022.v74i02.002 INTRODUCTION e know that the catalyst (or biochemical enzymes) plays an important role in the catalysis of many kind of reactions. Schiff base - complex have catalyzed many Name reactions and other reactions too. Schiff base complex plays a key role in various homogeneous catalytic reactions and the activity of these complexes changes with the type of ligands, coordination sites and metal ions. Survey of the Literature have shown that the coordination compounds have been used in human life as analgesic 1 , antibiotic 2 , antioxidative 3 , antifungal 4-5 , antibacterial 6-8 , antiviral 9 , antifertility 10 , antitoxic against insects 11 , antiulcer 12 , anti-HIV 13 and antitumor 14-15 , coating materials 16 , as catalysts in polymerization, oxidation, decomposition, hydrolysis and electro-reduction 17-18 , heat resistant adhesives 19 , electric insulating materials 20 , corrosion inhibitors 21 , dye and pigment industries 22 , pigments 23 , photographic developers 24 , plant growth regulators 25-26 , as models for molecules to absorb and release molecular oxygen reversibly similar to natural oxygen carriers like hemoglobin, hemocyanin and non- heme proteins 27 . Chiral Schiff bases transition metal complexes, so-called salen-type ligands, are one of the most studied chiral catalysts in asymmetric synthesis because of their ability to act as chiral catalysts or as co-catalysts 28-32 . Schiff-base ligands derived from salicylaldehyde and chiral amines have been widely applied in enantioselective cyclopropanation of styrenes 33 , asymmetric aziridination of olefins 34 , enantioselective epoxidation 35-36 , enantioselective ring opening of epoxides 37 , borohydride reduction of aromatic ketones, asymmetric oxidation of methyl phenyl sulfide 38 , enantioselective oxidation of silyl enol and trimethylsilylcyanation of benzaldehydes 39 . The E. Merck, in particular, has successfully developed a process for the industrial manufacture of antibacterial drug Cilastatin using chiral copper (II) Schiff-base complexes derived from salicylaldehyde and chiral amine 40 . Literature reports revealed that the large number of Schiff base metal complexes exhibit catalytic activities. Now-a- days it is well known that chiral Schiff base complexes are more selective in various reactions such as epoxidation, oxidation, aldol condensation and hydroxylation etc. 41 Progress on the catalytic activity of Schiff base - complexes in various reactions are outlined in this review. Some types of reaction catalysed by Salen 42 , salophen, salcyclo and different types of Schiff base catalysts are as follows: 1) Diels–Alder reaction 2) Epoxidation reaction 3) Oxidation reaction 4) Heck reaction 5) Michael addition 6) Aldol condensation reaction 7) Polymerization reaction 8) Hydrogenation reaction 9) Hydrogenation of imine 10) Hydrogenation of ketone 11) Hydrogenation of alkene and alkyne 12) Ring opening reaction of epoxide 13) Cyclopropanation reaction 14) Decomposition of hydrogen peroxide 15) C-C, C-H and C-Metal bond formation Catalytic studies on Complexes of Organic Compounds: Part-5. Review on use of Chiral Schiff base Complexes as Catalyst W Review Article