How to Cite: Anand, P., Mohanty, U., & Mani, S. (2022). Brain gym exercises and mirror box therapy in hemispatial neglect post-stroke: A randomised clinical trial. International Journal of Health Sciences, 6(S4), 3580–3593. https://doi.org/10.53730/ijhs.v6nS4.9339 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2022. Manuscript submitted: 9 March 2022, Manuscript revised: 27 May 2022, Accepted for publication: 18 June 2022 3580 Brain gym exercises and mirror box therapy in hemispatial neglect post-stroke: A randomised clinical trial Priyanka Anand Research scholar, Lovely Professional University, Jalandhar Prof. Umasankar Mohanty Professor, Manual therapy Foundation of India Dr. Suresh Mani Associate Professor, Lovely Professional University, Jalandhar Abstract---Background: Hemispatial neglect or unilateral neglect is a failure to report, respond, or orient to stimuli that are presented contralateral to a brain lesion, provided that this failure is not due to elementary sensory or motor disorders. There is a complete lack of awareness of one half of space, at which point, patients behave as if that half of the world does not exist. The estimated prevalence of hemispatial neglect after unilateral stroke is 30%. In this study, the differential treatment using brain gym exercises alone or in combination with Mirror Box therapy for hemispatial neglect post- stroke shall be analysed. Methods: This is a single blinded parallel randomised clinical trial consisting of 2 experimental. 121 participants who met the inclusion criteria were distributed randomly in 3 groups using systematic random sampling. Effect of mirror box therapy for one experimental group and brain gym exercises for second experimental group were calculated after 6 months post treatment. Statistical analysis of outcome measures was done before and after treatment using paired t-test and Anova.Results: 40 patients were randomised to MBT group (n=40), 40 to BGT group (n=40) and 40 to CG (n=40) after excluding the dropouts. There was improvement in scores of outcome measures: Catherine bergogo scale, Kessler foundation neglect assessment process (mean difference=), star cancellation test, singe letter cancellation test, double letter cancellation test, albert’s test, and bell’s test for groups MBT, MBBGT and BGT (95% CI, p<0.0001) before and after treatment, however, comparing group MBT, MBBGT and BGT, there was no significant improvement in scores. Conclusion: Within the groups: there was significant improvement in hemispatial neglect outcome measures in Group-A, B and C after treatment suggesting that brain gym exercises