A370 SLEEP, Volume 41, Abstract Supplement, 2018 memory consolidation, which is also impaired in SZ. We expected SX and FHR to show more overnight forgetting, compared to HC. Results: On the MST, patients showed slower typing. In terms of overnight improvement, HC, FHR, and nSZ showed similar improve- ment (13–22%), while SZ only showed 3% (p = .05, SZ vs all other groups). With regards to the WPT, HC and nSZ showed similarly small overnight forgetting (0 and 3%), while FHR and SZ showed signifi- cantly more forgetting (11 and 16%; p = .03). Age and sex were similar across groups. Conclusion: These results suggest impaired sleep-dependent procedural memory consolidation in early course schizophrenia patients, not present in those with a non-schizophrenia diagnosis. Furthermore, on a declarative task, relatives of schizophrenia patients showed impairment similar to the schizophrenia patients. Study of additional subjects is ongoing. Analyses correlating this behavioral results with deficits in sleep spindles - a pro- posed endophenotype for schizophrenia - will be presented. Support (If Any): NIH grants MH107579 and MH044832. 0999 CHARACTERIZING CLINICAL POPULATION DIFFERENCES IN TRANSIENT OSCILLATION FEATURES IN THE SLEEP EEG Stokes PA 1 , Rath P 1 , Manoach DS 1 , Stickgold R 3 , Prerau MJ 1 1 Massachusetts General Hospital, Charlestown, MA, 2 Massachusetts General Hospital, Charlestown, MA, 3 Beth Israel Deaconess Medical Center, Boston, MA Introduction: Sleep is traditionally characterized through patterns observed in the time-domain electroencephalogram (EEG). These include persistent oscillations, such as slow wave activity, or transient oscillatory activity, such as spindles and K-complexes. Time-domain identification of oscillations is difficult, with waveforms frequently being obscured by other oscillations and noise, limiting analyses to easily discernible waveforms. These difficulties lead to large inter- scorer variability—especially for transient oscillations like sleep spin- dles, the identification of which varies greatly depending on scorer or automated method used. This variability is a major challenge in ana- lysis of sleep differences in clinical populations, such as patients with schizophrenia (SZ), in whom cognitive deficits and symptoms correl- ate with measurements of spindle density based on traditional tech- niques. Here we demonstrate a new, objective analysis method that is agnostic to arbitrary criteria and robust to time-domain obfuscations, and that may offer improved characterization of the dynamics of sleep, its natural variation, and biomarkers of disease. Methods: We demonstrate a novel approach to the analysis of sleep EEG oscillations based on the observation that transient oscillations will appear as distinct peaks in the time-frequency spectrogram. By characterizing distributions of peak properties, rather than seeking to identify specific, pre-defined oscillations, we can perform defini- tion-agnostic analyses and comparisons of transient oscillatory activity across subjects or groups. We applied this approach to full-night EEG recordings from 21 SZ patients and 17 healthy controls and compared the peak feature distributions between the groups. Results: We found marked differences in the frequency distributions of time-frequency peaks between SZ and control participants, sug- gesting less frequent and less frequency-specific spindle-like peaks in SZ patients. The SZ distribution is also elevated over the control from 8-12Hz. The distribution of SZ peaks also suggests they are generally of smaller height than those of the control group. Conclusion: These results demonstrate that transient oscillations can be robustly identified and objectively analyzed in this definition-agnos- tic approach. Furthermore, this approach could more comprehensively characterize differences in clinical populations and reduce meth- od-based variability in spindle detection and other analyses. Support (If Any): R01NS096177; R01MH092638; K24MH099421. 1000 TARGETING SLEEP IN ADULTS SEEKING TREATMENT FOR CANNABIS USE DISORDER Martin EL 1 , Schlienz NJ 1 , Herrmann ES 2 , Budney AJ 3 , Lee DC 1 , Hampson A 4 , Smith M 1 , Leoutsakos JS 1 , Stitzer ML 1 , Vandrey RG 1 1 Johns Hopkins University School of Medicine, Baltimore, MD, 2 Battelle, Columbus, OH, 3 Geisel School of Medicine at Dartmouth, Lebanon, NH, 4 National Institute on Drug Abuse, Baltimore, MD Introduction: Sleep disturbance and strange/vivid dreams are among the most-reported symptoms of cannabis withdrawal, and acute cannabis administration has been shown to affect both sleep continuity and architec- ture. Many individuals with cannabis use disorder (CUD) cite these quali- ties as contributors to continued use. This research seeks to examine sleep quality in individuals seeking treatment for CUD, and assess the efficacy of a novel hypnotic intervention in increasing rates of abstinence. Methods: 127 adults seeking treatment for CUD and reporting a prior effect of cannabis use on sleep were enrolled in a 12-week clinical trial and randomized to receive either extended-release zolpidem or a pla- cebo. All were provided with computerized therapy modules (cMET/ CBT) and abstinence-based contingency management. In-home ambu- latory polysomnography (PSG) assessments measured changes in sleep architecture four times over the course of the study. Self-report measures of recent sleep (ISI, DBAS, PSQI) and urine specimens for toxicological testing were collected at bi-weekly study visits. Results: Individuals randomized to receive zolpidem demonstrated higher incidence of abstinence (clean urine) at any point during treat- ment (33.9% vs. 24.6%) and at end of treatment (27.4% vs. 15.4%). Sleep efficiency in the placebo group significantly decreased and sleep latency increased the first week after quit attempt initiated. Zolpidem attenuated abstinence-induced insomnia, but rebound sleep disturb- ance was observed after medication washout. Scores on the Insomnia Severity Index were consistently lower in the zolpidem group com- pared with placebo. Conclusion: Initial effect of cannabis withdrawal on sleep appears to be tempered by nightly zolpidem administration, and higher rates of abstinence in the treatment group were observed. Hypnotic medica- tion may be useful as an adjunct to behavioral treatments of cannabis use disorder to both facilitate initial abstinence and prevent relapse. Research on the type, dose and duration of hypnotic medication use to maximize therapeutic benefit and minimize rebound insomnia follow- ing discontinuation is required. Support (If Any): U01-DA031784, T32-DA0720. 1001 THE IMPACT OF ALCOHOL ON SLEEP DISORDERED BREATHING: A SYSTEMATIC REVIEW AND META-ANALYSIS Kolla B 1 , Foroughi M 1 , Saeidifard F 1 , Chakravorty S 2 , Wang Z 1 , Mansukhani M 1 1 Mayo Clinic, Rochester, MN, 2 Perelmen School of Medicine, Philadelphia, PA Introduction: Obstructive sleep apnea (OSA) is a common sleep-re- lated breathing disorder that results from complete or partial closure of the upper airway. Alcohol, a muscle relaxant, can potentially worsen B. Clinical Sleep Science and Practice IX. Sleep and Psychiatric Disorders Downloaded from https://academic.oup.com/sleep/article-abstract/41/suppl_1/A370/4989049 by guest on 04 July 2020