Itlal J. AL Asadi et al., Int. J. Res. Pharm. Sci., 2021, 12(1), 407-415 ORIGINAL ARTICLE INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACEUTICAL SCIENCES Published by JK Welfare & Pharmascope Foundation Journal Home Page: www.pharmascope.org/ijrps Endometrial compaction and serum progesterone measurements at the day of embryo transfer cannot predict pregnancy outcomes in frozen-thaw embryo transfer cycles Dalal M. Al Jarrah 1 , Manal Taha Al Obaidi 2 , Itlal J. AL Asadi *3 1 Department of Obstetrics and Gynaecology, Alzahraa Teaching Hospital, Najaf Ashraf-Iraq 2 High Institutes for Infertility Diagnosis and Assisted Reproduction Techniques, Baghdad-Iraq 3 Department of Invitro-Fertilization, Al Sadder Medical City, Najaf Ashraf- Iraq Article History: Received on: 29 Oct 2020 Revised on: 30 Nov 2020 Accepted on: 04 Dec 2020 Keywords: Endometrial Thickness, Frozen Embryo Transfer, Serum Progesterone Measurement ABSTRACT Endometrial receptivity plays a basic role in successful embryo implantation and pregnancy outcomes and can be assessed by many of non-invasive mark- ers. Our study evaluated the impact of two of these markers speciϑically serum progesterone and endometrial thickness at embryo transfer day in prediction pregnancy outcomes on (60) patients attempting medicated frozen embryo transfer (FET) cycles. All patients were received sequential estrogen & pro- gesterone medications for endometrial preparation then submitted to mea- surements of endometrial thickness (EMT) by transvaginal-ultrasound (TV- US) & serums progesterone (P) analysis at the embryo transfer day, there- after day 3 veriϑied-thawed embryos grades (A±B) were transferred. Com- pacted (decreased) EMT was seen in 48.3% of patients with higher pregnancy rate (PR) of 58.6%t than non-compacted EMT (no change or increased) which was seen in 51.7% of patients with (PR) of 29.0%, (P value=0.021). How- ever ongoing pregnancy rate (Ong PR) not differed signiϑicantly between both groups (44.8% in compacted vs 25.8% in non-compacted, P value=0.053), also the means of serum P not differed between pregnant and non-pregnant patients (P value=0.374). ROC curves for Ong PR prediction in relations to endometrial compaction & serum progesterone at embryo transfer day were poor (AUC= 0.630, & AUC=0.576, respectively). This study suggested that endometrial compaction or serum P levels measurements at embryo trans- fer day were poor predictors for ongoing pregnancy where any kind of EMT changes (decreased or not) seen after P administration not signiϑicantly affect pregnancy outcomes in frozen-thaw cycles of cleavage stage embryos transfer. * Corresponding Author Name: Itlal J. AL Asadi Phone: 009647823561659 Email: Itlal.asadi@gmail.com ISSN: 0975-7538 DOI: https://doi.org/10.26452/ijrps.v12i1.4050 Production and Hosted by Pharmascope.org © 2021 | All rights reserved. INTRODUCTION In our time frozen-thaw embryo transfer considers as a fundamental part of IVF cycles owing to the availability of advance cryopreservation techniques, its safety & increment of cumulative life birth rates (LBR) (Bosch et al., 2020). However, its implan- tation and pregnancy rates are not always supe- rior compared to fresh cycles (Basirat et al., 2016). Recent attention has been paid more toward the endometrium since both euploid embryo & recep- tive endometrium sharing as equal as a role in deter- mining embryo implantation and pregnancy out- © International Journal of Research in Pharmaceutical Sciences 407