Research Article Cognition/Psychological Burden and Resilience in Cutaneous T- Cell Lymphoma and Psoriasis Patients: Real-Life Data and Implications for the Treatment Giovanni Damiani , 1,2 Joselin D. Tacastacas , 1 Timothy Wuerz , 3,4,5 Lindsay Miller , 3 Philip Fastenau , 3 Christopher Bailey , 3 Mansi Chawa Sethi , 2 Amanda Argenas , 6,7 Marco Fiore , 8 Kevin D. Cooper , 1 and Alan J. Lerner 3 1 Department of Dermatology, University Hospitals Cleveland Medical Center, And Case Western Reserve University, Cleveland, OH, USA 2 Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy 3 Department of Psychiatry, Henry Ford Hospitals, Detroit, MI, USA 4 Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA 5 Los Angeles County Department of Mental Health, Redondo Beach, CA, USA 6 Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA 7 Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA 8 Department of Women, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Naples, Italy Correspondence should be addressed to Marco Fiore; marco.fiore@hotmail.it Received 30 December 2021; Revised 14 June 2022; Accepted 28 June 2022; Published 21 July 2022 Academic Editor: Mouldy Sioud Copyright © 2022 Giovanni Damiani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Psoriasis and cutaneous T-cell lymphoma (CTCL) expose patients to chronic inflammation as well as physical and psychological disabilities, but the impact of such alterations on cognitive function is unknown. Objective. This study is aimed at determining if CTCL and psoriasis impact cognitive functioning in relation to psychological and health-related quality of life (HR-QOL) status. Methods. A cross-sectional study was performed in an outpatient dermatology clinic of a university teaching hospital. Thirty-nine subjects with CTCL (N = 20) or psoriasis (N = 19) who met eligibility criteria were included. The cognitive domains of memory, attention and processing speed, and executive function were assessed with standard neuropsychological tests. Subjects were assessed for depression, anxiety, and HR-QOL (using the SKINDEX-29 questionnaire). Results. Study participants were CTCL and psoriasis subjects; cognitive impairment was found in the domain of memory in 17.9% subjects with CTCL or psoriasis. Lower scores on executive function tests were predicted by higher (worse HR-QOL) SKINDEX-29 functioning scores (p =0:01). A higher estimated baseline intellectual functioning predicted lower scores (better HR-QOL) on the symptoms and functioning domains of SKINDEX-29 (p =0:01 and 0.02, respectively) and a statistical trend (p =0:07) for the emotion domain. Memory and acute anxiety were adversely impacted by shorter disease duration (p =0:01 for both). Conclusions. Memory impairment may be associated comorbidity in CTCL and psoriasis. Subjects with stronger cognitive resources appear to cope better with health-related quality of life (HR-QOL) challenges. 1. Introduction Chronic skin diseases, both inflammatory and neoplastic, may couple with a systemic inflammatory status leading to physical and psychological disabilities [1–3]. The real impact of systemic inflammation on cognitive function is still debated, and few dermatological studies have explored this link; however, differences in both methods and subsets of analyzed patients make their comparison problematic [4–8]. Interestingly, both skin diseases and mild cognitive Hindawi BioMed Research International Volume 2022, Article ID 8802469, 10 pages https://doi.org/10.1155/2022/8802469