Original Contribution Postoperative analgesic efficacy of fascia iliaca block versus periarticular injection for total knee arthroplasty ☆ Cagla Bali MD (Specialist) a,b, ⁎ , Ozlem Ozmete MD (Specialist) a,b,1 , H. Evren Eker MD (Assoc. Prof) a,b,2 , Murat A. Hersekli MD (Prof) b,c,3 , Anis Aribogan MD (Prof) a,b,4 a Baskent University School of Medicine, Anesthesiology and Reanimation Department, Adana Teaching and Research Center, Adana, Turkey b Baskent Universitesi Tip Fakultesi Adana Uygulama ve Arastirma Merkezi Dadaloglu, Mh.39. Sk. No.6 01250, Yuregir, Adana, Turkiye c Baskent University School of Medicine, Department of Orthopedics and Traumatology, Adana Teaching and Research Center, Adana, Turkey Received 23 January 2016; revised 1 August 2016; accepted 9 August 2016 Keywords: Fascia iliaca block; Periarticular drug injection; Total knee arthroplasty Abstract Study objective: This study evaluated the postoperative analgesic efficacies of fascia iliaca block and peri- articular drug injection techniques after TKA (total knee arthroplasty) surgeries. Design: Prospective, randomized clinical trial. Setting: University Teaching and Research Center. Patients: Seventy-one American Society of Anesthesiologists (ASA) I-III patients between 48 and 70 years of age who underwent total knee arthroplasty were randomized. Interventions: Tenoxicam (20 mg) was administered intramuscularly to both groups of patients 30 minutes before surgery. Patients were randomized into two groups to receive fascia iliaca block before the induction of anesthesia (Group FI) or periarticular drug injection during the surgery (Group PI). All surgeries were per- formed under general anesthesia using standard techniques. Postoperative analgesia was provided with patient-controlled intravenous morphine. Measurements: Total morphine consumption was the primary outcome measure and was recorded postop- eratively at 1, 2, 6, 12 and 24 hours. Pain levels at rest and on movement (knee flexion) were evaluated using the Visual Analogue Scale (VAS) and recorded at the same time points. Patients' demographics, rescue an- algesic demands, side effects, hemodynamics, and satisfaction scores were also recorded. ☆ Clinical Trials.gov Identifier: NCT02047331. ⁎ Corresponding author at: Baskent Universitesi Tip Fakultesi Adana Uygulama ve Arastirma Merkezi Dadaloglu, Mh. 39. Sk. No.6 01250, Yuregir, Adana, Turkey. Tel.: +90 322 3272727x1472, +90 532 0613026 (Mobile); fax: +90 322 3271273. E-mail address: caglaetike@hotmail.com (C. Bali). 1 Tel: +90 322 3 272 727, +90 536 6 965 114 (Mobile); fax: +90 322 3 271 273. 2 Tel.: +90 322 3272727x1469, +90 505 748 20 38 (Mobile); fax: +90 322 3 271 273. 3 Tel.: +90 322 3 272 727, +90 532 354 44 15 (Mobile); fax: +90 322 3 271 273. 4 Tel.: +90 322 3 272 727, +90 532 2 148 661 (Mobile); fax: +90 322 3 271 273. http://dx.doi.org/10.1016/j.jclinane.2016.08.030 0952-8180/© 2016 Elsevier Inc. All rights reserved. Journal of Clinical Anesthesia (2016) 35, 404–410