J Obes Nutr Disord, an open access journal ISSN: 2577-2244 1 Volume 4; Issue 01 Journal of Obesity and Nutritional Disorders Research Article Minh LTA, et al. J Obes Nutr Disord 1: 136. Which Triglycerid-Glucose Indexs can be Applied in the Diagnosis of Insulin Resistance in Vietnamese Metabolic Syndrome Patients with or without Hypertension? To Anh Tuan 1 , Le Thi Anh Minh 1 , To Muoi 1 , Hoang Anh Tien 2 , Huynh Van Minh 2* 1 Department of Cardiology, North QuangNam hospital, Vietnam 2* Department of Internal Medicine, University of Medicine and Pharmacy, Hue University, Vietnam * Corresponding author: Huynh Van Minh, Professor, Department of Internal Medicine, University of Medicine and Pharmacy, Hue University, 6 NgoQuyen Street, Vietnam. Tel: +84-914062226, Fax: +84-234.3826269; Email: hvminh@huemed-univ.edu. vn Citation: Tuan TA, Minh LTA, Muoi T, Tien HA, Minh HV (2019) Which Triglycerid-Glucose Indexs can be Applied in the Diagnosis of Insulin Resistance in Vietnamese Metabolic Syndrome Patients with or without Hypertension? J Obes Nutr Disord 1: 136. DOI: 10.29011/2577-2244.100036 Received Date: 14 September, 2019; Accepted Date: 10 October, 2019; Published Date: 15 October, 2019 DOI: 10.29011/2577-2244.100036 Abstract Objective: To evaluate the triglycerid-glucose indexs (TyG, TyG-BMI and TyG-WC) in measurement insulin resistance and the correlation between the triglycerid-glucose indexs with conventional HOMA-IR index in Vietnamese metabolic syndrome patients with or without hypertension. Subjects and methods: A cross-sectional study of 69 patients with mean age 64,96 ± 14,01 with metabolic syndrome in Heart Center, Hue Central hospital and were diagnosed of MS according to NCEP-ATP III 2009 included in the study. Results: The percentage of insulin resistance of metabolic syndrome patients was 44,9%. The mean value of the index TyG, Tyg-BMI and TyG-WC respectively were 4,56 ± 0,52, 102,21 ± 18,59 and 399,29 ± 52,85. There was no difference in TyG, TyG-BMI and TyG-WC among metabolic syndrome patient with and without hypertension (p > 0,05). There was the positive correlation between TyG index with HOMA-IR index in patient with metabolic syndrome (r = 0,488, p < 0,001), insulin resis- tance (r = 0,482, p < 0,05), non-insulin resistance (r = 0,407, p < 0,05). TyG-WC had the association with HOMA-IR in patient with metabolic syndrome (r = 0,327, p < 0,05), non-insulin resistance (r = 0,482, p < 0,05). TyG was signifcantly a independent prediction insulin resistance with OR = 3,362 (KTC95% 1,211 - 9,303). The TyG index was signifcantly different between insulin resistance and non-insulin resistance patient (p < 0,05). Conclusion: The study showed that there was a difference in the TyG index between Vietnamese metabolic syndrome patients with and without insulin resistance. There was a moderate correlation between the TyG index and the HOMA-IR index. TyG is a independent predictor but it need the further studies to defne whether TyG index can be used to evaluating the insulin resistance in metabolic syndrome. Keywords: Arterial hypertension; Metabolic syndrome; Triglyceride-Glucose index, TyG-BMI and TyG-WC index Introduction Insulin resistance is a decrease in the sensitivity of insulin to muscle and adipose tissue, reducing the liver’s ability to metabolize glucose [1]. Otherwise, Insulin resistance is considered a factor to increase the risk of developing type 2 diabetes and cardiovascular disease, increasing the mortality [2]. For that reason, insulin resistance should be detected and diagnosed early before progressing to more serious illnesses later. Metabolic syndrome (MS) is a compound of important risk factors, among which the background was insulin resistance [3]. Insulin resistance is the cornerstone of increased risk in patients with MS. Based on the effects of triglycerid metabolism products and changes in fasting blood glucose that affect insulin sensitivity Triglycerid/Glucose Indexs (TryG index) has been shown by many studies to be strongly associated with the Homeostatic model assessment HOMA-IR