DOI: 10.14260/jemds/2015/710 CASE REPORT J of Evolution of Med and Dent Sci/ eISSN- 2278-4802, pISSN- 2278-4748/ Vol. 4/ Issue 28/ Apr 06, 2015 Page 4893 LIPOLEIOMYOMA OF UTERUS: A CASE REPORT Mahendra Singh 1 , Rachita Gulati 2 , Adrija Pathak 3 , Yogendra Verma 4 , Neelima Sachaan 5 HOW TO CITE THIS ARTICLE: Mahendra Singh, Rachita Gulati, Adrija Pathak, Yogendra Verma, Neelima Sachaan. “Lipoleiomyoma of Uterus: A Case Report”. Journal of Evolution of Medical and Dental Sciences 2015; Vol. 4, Issue 28, April 06; Page: 4893-4896, DOI: 10.14260/jemds/2015/710 ABSTRACT: INTRODUCTION: Fatty tumours of the uterus are exceedingly rare. Lipoleiomyoma of the uterus is a rare benign uterine tumour thought to be a variation of leiomyoma. The presence of fatty tissue in the myometrium is anomalous, interpreted as lipomatous degeneration, smooth muscle metaplasia or as a benign tumour called as lipoleiomyoma. The incidence is variously reported as 0. 03–0. 2%. Case Report- here we present a case of 58 years old postmenopausal woman with submucosal fibroid. Discussion- we confirmed our diagnosis of lipoleiomyoma by gross and microscopic findings. KEYWORDS: Lipoleiomyoma, Postmenopausal, Uterus. INTRODUCTION: Uterine leiomyomas are extremely common neoplasms with a quoted incidence of 4–11% and mainly seen (40%) in women over 50 years. [1] Many variants which are the result of secondary changes have been described and are detectable in around 65% of cases. Lipoleiomyoma is an alteration that was previously called as fatty metamorphosis, lipomatous degeneration, adipose metaplasia, etc. It is now regarded as a distinct true neoplasm. In spite of relatively common occurrence of leiomyomas of uterus, lipoleiomyomas are rare variants of uterine leiomyoma. The incidence is variously reported as 0.03–0.2%. [2,3] CASE REPORT: A 58 years old postmenopausal woman presented with complaints of pain in the lower abdomen and bleeding per vaginum on and off. The patient's history revealed that she had attained menarche at the age of 14 years, had regular menstrual cycles of 4–5 days duration at 28 days interval. She had attained her menopause 5 years back. Gynaecological examination revealed unhealthy cervix. Per abdomen findings showed tender and bulky uterus. Ultrasound showed a solitary hyperechoic mass in the myometrium of the uterus measuring 3.5×3cm. Abdominal hysterectomy was done for the same. On gross examination of the specimen uterus and cervix together measured 9×5×3cm. On cut section there was a sub mucosal fibroid measuring 3x3 cm shifting the endometrial cavity to one side. Cut section of the fibroid was solid grayish white with a whorled appearance. The periphery of the fibroid was pale yellow and softer in consistency as compared to the rest of the fibroid. Paraffin embedded sections were prepared stained with hematoxylin and eosin. Microscopically, sections from the fibroid showed a well encapsulated mass of proliferating benign spindle shaped smooth muscle cells without any atypia and forming a whorled appearance admixed with mature adipocytes. The adipocytes were completely benign looking with no lipoblasts. Endometrium showed mild hyperplasia of the glands. Cervix showed chronic cervicitis. DISCUSSION: Lipomatous uterine tumors can generally be subdivided into two types: pure or mixed lipomas. [4,5] The latter consist of lipoleiomyoma, angiomyolipoma, fibrolipoma. A third group of