North American Academic Research , Volume 3, Issue 11; November, 2020; 3(11)170-189 © TWASP, USA 170 + North American Academic Research Journal homepage: http://twasp.info/journal/home Research Anti-inflammatory Activities of Different Types of Yemeni honey on Rats Mohammed S. A. Al-Awar 1 *, Talal Ali Hussein Al-Qalah 2 , Abduljalil D. S. Ghaleb 3 , Marwan M. A. Rashed 4 1 Department of Microbiology, Faculty of Applied Science, Amran University, Yemen. 2 Department of Nursing, Faculty of Medicine and Health Science, Amran University, Yemen. 3 Faculty of Applied and Medical Science, AL-Razi University, Al-Rebatt St., Sana'a ye700, Yemen. 4 School of Biological and Food Engineering, Suzhou University, Bianhe Middle Road 49, Yongqiao, Suzhou 234000, Anhui Province, China. * Corresponding author Accepted: 29 October,2020; Online: 18 November, 2020 DOI : https://doi.org/10.5281/zenodo.4279955 Abstract: This study aimed to evaluate the anti-inflammatory activities of eight different types of Yemeni honey using an acute inflammation rat model. Ten groups were employed in this study (n = 8 rats for each group), Rats paw edema was induced by sub plantar injection of 1% carrageenan into the right hind paw. Rats were pre-treated with different types of Yemeni honey (Osaimi sider, Athel, Al-Akhawain, Salam, Somar, Majra, Acacia and Algasas) at a dose (5mg/kg b.w) and NSAID as Indomethacin (10 mg/kg, p.o.) for 7 days. The diameter of the hind paw was measured for assessment of the edema size at 1, 2, 4, 6 and 24 hours. The different types of Yemeni honey significant anti-inflammatory efficacies against carrageenan-induced paw edema in rats. Besides, the different types of Yemeni honey, elevate numbers of RBCs, Hb and PCV with a reduction in WBCs numbers. Marked reduction in percentages of neutrophil, lymphocyte and basophils. Moreover, they succeeded to reduce the elevated serum AST level. Algasas honey and osaimi sider honey possesses a better anti-inflammatory activity which was almost similar to the effect of the Indomethacin, followed Dam Al-Akhawain honey (Acacia honey). Where Athel, Salam and Somar honey, their anti-inflammatory activity differed according to the source and the level of honey. Therefore, these discrepancies could be attributed to the differences of botanical sources of honey and also to the presence of different compounds of anti-inflammatory that have different anti-inflammation effects. Conclusion: The different types of Yemeni honey (Osaimi sider, Athel, Dam Al-Akhawain, Salam, Somar, Majra, Acacia and Algasas) possess anti-inflammatory activity. Also, they were safe at the doses used. Keywords: Anti-inflammatory activities; Yemeni honey types; Hematological Assay; Animal experimental Design