Accepted Manuscript Expression of stable and active human DNA topoisomerase I in Pichia pastoris Mooi Kwai Chan, Shern Kwok Lim, Noorizan Miswan, Ai Lan Chew, Rahmah Noordin, Boon Yin Khoo PII: S1046-5928(17)30331-5 DOI: 10.1016/j.pep.2017.09.003 Reference: YPREP 5155 To appear in: Protein Expression and Purification Received Date: 1 June 2017 Revised Date: 11 August 2017 Accepted Date: 7 September 2017 Please cite this article as: M.K. Chan, S.K. Lim, N. Miswan, A.L. Chew, R. Noordin, B.Y. Khoo, Expression of stable and active human DNA topoisomerase I in Pichia pastoris, Protein Expression and Purification (2017), doi: 10.1016/j.pep.2017.09.003. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.