ENGIGRAR ANIGIRO P J M H S Vol. 12, NO. 4, OCT – DEC 2018 1793 Determine the Mortality Rate of patients with Gastrointestinal Bleeding Admitted to the Emergency Unit FARZAD BOZORGI 1,2,3 ; SEYED JABER MOSAVI 4,3 ; TORAJ ASADI 2,3 *; IRADJ MALEKI 2 , SEYED MOHAMMAD HOSSEININEJAD 4,2,3 , SEYED MASUOME PASHAIE 3 , SEYYED HOSEIN MONTAZAR 3 , IRAJ GOLI KHATIR 3 , BAHRAM DASHTI 3 ABSTRACT Background: gastrointestinal bleeding are very common cases in emergency departments and is the most common reason for hospital admission.Gastrointestinal bleeding is a life-threatening condition that causes death and serious complications, clinical and considerable economic times and admission to hospital for immediate diagnosis and treatment is very important. Methods: This Cross-sectional study on 340 patients with GI bleeding referring to Imam Khomeini hospital in Sari patients hospitalized during the transfusion, transfer to ICU, surgery and mortality will be the follow-up. As well as age, sex, length of hospital stay for patients with the disease will be recorded and data analysis will be done by SPSS software. Results: After examining the records and statistical analysis found that of the 340 patients we studied, 206 (60.6%) male and 134 (39.4%) were female. Analysis was conducted on the data showed that the average age of patients was 19.8 ± 57.16 youngest patient was 9 years old and the oldest 114 years. Racially in 337 patients showed that 311 patients (91.5%) subjects were from Mazandaran province, 8 patients (2.4%) leave, 5 patients (1.5%) Turkmen, three of them was kord (0.9%), 1 Arab (0.3%), and 9 (2.6%) were Persian. Between PPI use and the results of endoscopic significant relationship was found (P = 0.028), of 278 patients GIB, 233 patients (83.8%) UPPER affecting the digestive system and 45 patients (16.2%) LOWER and the findings of 272 patients upper gastrointestinal endoscopy were related to the 233 system, constituted 85.6% of .there was a significant relationship between T increased, BUN and endoscopic findings (P = 0.001), increasing CR and endoscopic findings (P = 0.001) and an decrease in HB and endoscopic findings (P = 0.034). Conclusion: Between sex and the difference between the results of endoscopic digestive problems in the upper gastrointestinal or lower gastrointestinal tract, there was no significant relationship (P = 0.149). Between age and endoscopic findings there was a significant relationship (P = 0.007). There is no significant relationship between race and digestive problems (P = 0.203). 262 patients (77.1%) were hospitalized in public department, and 41 (12.1%) were hospitalized in ICU and 21 patients (6.2%) died. Between endoscopy results and outcomes of patients there was a significant relationship (P = 0.001) . Key words: Outcome - gastrointestinal bleeding - Emergency Department INTRODUCTION In developed countries, the annual incidence of hospital admissions for gastrointestinal bleeding (GIB) is approximately 1% and the mortality rate is about 5 to 10 percent 1,2 . Peptic ulcers are the most common cause of upper gastrointestinal bleeding and almost half of cases 3 . In addition to clinical protests, Profile ulcer on endoscopy can provide important information about its prognosis 4 . Several clinical trials have shown that continuous infusion of high- ------------------------------------------------------------------------------- 1 Orthopedic Research Center, Mazandaran University Of Medical Sciences, Sari, Iran 2 Gut and Liver Research Center , Mazandaran, University of Medical Sciences, Sari, Iran 3 Department of Emergency medicine, Faculty of Medicine, Mazandaran University Of Medical Sciences, Sari, Iran 4 Diabetes research center, Mazandaran university of Medical Sciences, Sari, Iran 5 Assistant Profeesor of Medical Oncology and Hematology, Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran 6 Assistant Professor of Community Medicine, Education Development Center, Mazandaran university of Medical Sciences, Sari, Iran Correspondence to Dr. Toraj Asadi, Email:farzadbozorgi1356@gmail.com dose intravenous PPI to slow the bleeding was coming. Prevention of recurrent bleeding is based on three main factors in the pathogenesis of Helicobacter pylori ulcer-like, NSAID and increase acid secretion. Eradication of Helicobacter pylori infection in this group of patients, the risk of re-bleeding severely reduced to less than 5% lead 5,6 . GIB and abrasion would occur due to NSAID use, alcohol and stress. Stress-induced gastric mucosal injury in critically ill patients due to severe trauma, major surgery, burns over the body, the disease occurs mainly intracranial bleeding disorders 7,8,9,10,11 . Other causes of rare bleeding from the upper gastrointestinal tract are neoplasm, fistula, vascular lesions, including Telangiectasia inherited bleeding ectasia vessels in the gastric antrum, the lesion Dieulafoy, Gastropaty of prolapse, hemobilia and etc. The most common sources of bleeding from the small intestine causes include vascular tumours (such as adenocarcinoma, leiomyoma, lymphoma, benign polyps, carcinoid, metastases and lipoma and wear and ulcers caused by NSAID). Other rarer causes include Crohn's disease, infections, ischemia, vasculitis, varices of the small intestine, diverticulum, Meckel's diverticulum, cysts caused by condensation plug intestine, and colon emboli. Meckel's diverticulum is the most