International Journal of Research in Medical Sciences | September 2018 | Vol 6 | Issue 9 Page 2999 International Journal of Research in Medical Sciences Singh GV et al. Int J Res Med Sci. 2018 Sep;6(9):2999-3003 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 Original Research Article Clinico-physiological profile of patients of pulmonary impairment after tuberculosis at a tertiary care centre Gajendra V. Singh 1 , Antriksh Srivastava 2 *, Vinisha Chandra 2 , Santosh Kumar 1 , Rishabh Goel 1 INTRODUCTION Pulmonary TB survivors frequently experience structural and functional lung sequels that vary in severity that have recently been more completely described. 1 Pulmonary tuberculosis (TB) can cause parenchymal destruction by up-regulation of several proteases and dysregulation of protease control. 2 The histopathological abnormalities after treatment for pulmonary TB include fibrosis, bronchiectasis, and bronchial stenosis, all of which can cause pulmonary function abnormalities. 3,4 Pulmonary impairment after tuberculosis was recently described as a non-fatal negative health effect. 5-7 Pulmonary impairment after tuberculosis (PIAT) refers to chronic pulmonary function loss that occurs in persons who have achieved microbiologic cure of pulmonary tuberculosis. Levels of impairment were determined in previous studies via spirometry using American Medical Association's Guide to Evaluations on Permanent Impairment (fifth edition). 8 Impairment was scaled none, mild, moderate, or severe. In India, the burden of tuberculosis is very high due to a multiplicity of causes such as overcrowding, poor hygiene conditions and lack of orientation towards role of early diagnosis and treatment of the disease. Patients approach the physician very late after onset of the disease when the pulmonary impairment has established itself to a great extent. In this 1 Department of T.B. and Chest Diseases, S. N. Medical College, Agra, Uttar Pradesh, India 2 Department of Respiratory Medicine, School of Medical Sciences and Research, Greater Noida, Uttar Pradesh, India Received: 11 June 2018 Accepted: 05 July 2018 *Correspondence: Dr. Antriksh Srivastava, E-mail: antriksh0105@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: Pulmonary tuberculosis (TB) is a unique infectious disease that more often results in permanent structural changes in the lung parenchyma. It is by virtue of these changes that the patients even after bacteriological cure continue to suffer the after effects of the disease. Objective of study was to assess the clinico-physiological profile of patients of pulmonary impairment after tuberculosis (PIAT) attending S. N. Medical College, Agra, Uttar Pradesh, India. Methods: Over the time period of 2 years, 350 patients of healed pulmonary tuberculosis were identified and studied about their clinico-physiological profile. This profile included age, sex, category of treatment, pulmonary function test pattern, exercising capacity, exercise tolerance and quality of life. Results: It was found that majority of the patients were males, >60 years of age and had taken Category-II treatment. Most of the patients were having an obstructive pattern on PFT, poor exercise tolerance and exercise capacity and a poor quality of life. Conclusions: Patients of healed pulmonary TB continue to experience respiratory symptoms owing to the permanent anatomical changes in the lung conferred by the disease. Keywords: Healed Pulmonary TB, PIAT, Pulmonary impairment DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20183633