Submit Manuscript | http://medcraveonline.com Introduction Today laparoscopic surgery is common for operations including radical prostatectomy, nephrectomy, adrenalectomy and other complex surgeries. The patients having laparoscopic surgeries experience postoperative pain, especially in the upper and lower abdomen, back and shoulder region. Pain intensity usually peaks during the frst postoperative hours and usually declines over the following two to three days.. It is important to prevent adverse efect such as tachycardia, hypertension, myocardial ischemia, decrease in alveolar ventilation, and poor wound healing caused by pain. Various studies has been conducted in animal and The humans to prove that Vitamin C can be used as a component of multimodal analgesia. It is a water soluble vitamin which exerts its anti-nociceptive properties through its antioxidant action by neutralizing the reactive oxygen species formed during the stress of surgery. 1,2 In addition it has also role in modulating the sensitization of pain through its action on NMDA receptor. Laparoscopic surgeries are routinely performed therefore it is desirable to have proper pain control for the early discharge of patients from hospital. Material and methods After approval from Institute research ethical committee and patient informed written consent, a prospective randomized double blind study was conducted on 200 patients of ASA physical status 1 and 2, age between 18 to 75 years who were scheduled for laparoscopic surgeries. The patients were excluded from study who refused to participate in study and Patients who have chronic pain and received anti infammatory drug 24 hour before surgery. All the selected patients were divided in to 2 groups. Group 1 received vitamin C 2gram and group 2 patients received placebo tablets in the night and 2 hour before surgery. All patients were given tablet ranitidine 150mg and tablet metoclopramide 10 mg in evening and 2 hour before surgery. Patients were explained about surgical procedure and visual analogue pain scale (VAS, 0: no pain and VAS 10: worst pain). In operative room monitors (ECG, noninvasive blood pressure, SpO2 probe, EtCo2) were attached and base line parameters were recorded. Injection fentanyl 2microgm /kg and injection midazolam 30 micro gm/kg body weight given before induction. Anesthesia was induced with propofol 2mg/kg and vecuronium bromide 0.1mg/kg as muscle relaxant. After intubation anesthesia was maintained with oxygen, nitrous oxide (50:50) and isofurane. Patients in both group received injection paracetamol 10mg/kg body weight 30 minutes before skin closure. Neuromuscular blockade was reversed with neostigmine 0.05mg/kg and glycopyrrolate 0.02mg/kg intravenously. Patients were transferred to postoperative recovery room after adequate recovery. Pain severity was assessed using VAS score. Hemodynamic parameters and VAS score were recorded at 0 min30 min, 60 min, 90min, 120 min and 240 minutes in postoperative period. Injection fentanyl 25 microgram IV was given as rescue analgesic when patient J Anesth Crit Care Open Access. 2016;5(1):14‒12. 1 ©2016 Kumar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestrited use, distribution, and build upon your work non-commercially. Vitamin C premedication reduces postoperative rescue analgesic requirement after laparoscopic surgeries Volume 5 Issue 1 - 2016 Atchya Arun Kumar, 1 Ram Badan Singh, 2 Avantika singh 3 1 Junior Resident, Department of Anaesthesiology, Institute of Medical Sciences Banaras Hindu University, India 2 Professor, Department of Anaesthesiology, Institute of Medical Sciences Banaras Hindu University, India 3 Junior Resident, Department of Anaesthesiology, Eara Medical College Lucknow, India Correspondence: Ram Badan Ram, Banaras Hindu University, Department of Anaesthesiology, Institute of Medical Sciences, BHU,Varanasi 221005, Uttar Pradesh, India, Tel +91 9336910579, Email Received: May 31, 2016 | Published: June 16, 2016 Abstract Background & Objectives: Pain is one of the common medical causes of delayed discharge from hospital. It causes adverse efect such as tachycardia, hypertension, myocardial ischemia, decrease alveolar ventilation, and poor wound healing. The reduction of pain may prevent these adverse efects and enhance early discharge from hospital. The premedication with oral vitamin C was assumed to reduce postoperative pain and rescue analgesic requirement in patients after laparoscopic surgeries. Material and Methods: After approval from ethical committee and informed written consent, study was conducted on 200 patients of ASA physical status 1 and 2, who were scheduled for laparoscopic surgery. All the selected patients were divided in to 2 groups. Group 1 received oral vitamin C 2 gram and group 2 patients received placebo tablets in night and 2 hour before surgery. After premedication Patients were explained about surgical procedure and visual analogue pain scale (VAS 0: no pain and VAS 10: worst pain). Anesthesia was induced with propofol 2mg/kg and vecuronium bromide 0.1mg/kg as muscle relaxant and maintained with oxygen, nitrous oxide (50:50) and isofurane. Patients in both group received injection paracetamol 10mg/kg body weight 30 minutes before skin closure. Neuromuscular blockade was reversed and patients were shifted in postoperative recovery room. The data were recorded and analyzed. Results: The physical variables of both group patients were statistically comparable. Mean heart rate, blood pressure VAS score were statistically diferent in early part of postoperative period. The postoperative analgesic consumption in group 1 patients were signifcantly low. Conclusion: We concluded that use of vitamin C reduces early postoperative pain and consumption of fentanyl as rescue analgesic in postoperative period. Keywords: anaesthesia, postoperative pain, vitamin C, rescue analgesic Journal of Anesthesia & Critical Care: Open Access Research Article Open Access