International Journal of Research in Medical Sciences | July 2020 | Vol 8 | Issue 7 Page 2477 International Journal of Research in Medical Sciences Ikpeme EE et al. Int J Res Med Sci. 2020 Jul;8(7):2477-2481 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 Original Research Article Incidence of acute kidney injury in asphyxiated babies in university of Uyo teaching hospital, Uyo, Nigeria Ikpeme Enobong Emmanuel 1 *, Dixonumo Ofonime Tony 1 , Udoh Mary Paulinus 1 , Udo Jacob J. 2 INTRODUCTION Acute kidney injury (AKI), the term that has replaced the term Acute Renal Failure (ARF) is defined as an abrupt (within hours) decrease in kidney function, which compasses both injury (structural damage) and impairment (loss of function).¹ It is characterized by a reversible increase in blood concentration of creatinine and nitrogenous waste products and inability of the kidneys to regulate fluid and electrolyte homeostasis appropriately. 1 The Acute Dialysis Quality Initiative (ADQI) group standardized the definition of AKI using the RIFLE criteria, a mnemonic for three levels of severity; Risk, Injury and Failure and two outcomes; Loss of kidney function and End-stage kidney disease. 1,2 The Acute Kidney Injury Network (AKIN) devised strata that defined AKI based on time in relation to absolute creatinine increase, percentage increase, or documented oliguria. 3 A new consensus definition merging the RIFLE 1 Department of Pediatrics, University of Uyo Teaching Hospital, PMB 1136, Uyo, Akwa Ibom State, Nigeria 2 Department of Pediatrics, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria Received: 13 May 2020 Accepted: 06 June 2020 *Correspondence: Dr. Ikpeme Enobong Emmanuel, E-mail: enobong.ikpeme@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: Acute Kidney Injury (AKI) is a consequence of birth asphyxia. In resource poor countries like ours, birth asphyxia still contributes to the high rates of neonatal morbidity and mortality. A few studies have reported the incidence of AKI in birth asphyxia in Nigeria but none from Uyo, south-south region of Nigeria. Methods: A descriptive cross sectional study carried out in the Newborn Unit of the University of Uyo Teaching hospital, Uyo, Nigeria over a period of eight months. One hundred and four term neonates with provisional diagnosis of birth asphyxia using Apgar scoring were recruited. Blood sample was collected within six hours of life from each subject for serum creatinine estimation using modified Jaffe method. Urine output was assessed by application of plastic collection bag to the skin by adhesive patch. AKI was diagnosed when sCr >1.5mg/dl while oliguria was defined as urinary output <1.5ml/kg/hour. Results: Of the total of 104 asphyxiated neonates enrolled into the study, 56 (53.8%) were males while 48 (46.2%) were females giving a male/female ratio of 1.2:1. Twenty-eight (26.9%) of the subjects had severe birth asphyxia; 52 (50%) had moderate birth asphyxia while 24 (23.1%) were mildly asphyxiated. Incidence of AKI was 48 (46.1%), twelve (11.5%) had AKI based on serum creatinine criteria while 36 (34.6%) had AKI based on urinary output criteria. The mean urinary output (ml/kg/hr) for the subjects was 1.65±0.68 while the mean serum creatinine (mg/dl) was 0.88±0.46. Conclusions: The incidence of AKI among asphyxiated neonates in our locale is high at 46.1%. Keywords: Acute kidney injury, Birth asphyxia, Incidence, Neonates DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20202882