How to Cite: Al-sayed, E. A.- sayed H., Shafik, S. A., Gomaa, A. A. A., & El-Zayat, O. S. (2022). Caregivers burnout of their children with thalassemia. International Journal of Health Sciences, 6(S4), 6546–6563. https://doi.org/10.53730/ijhs.v6nS4.9849 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2022. Manuscript submitted: 27 March 2022, Manuscript revised: 9 May 2022, Accepted for publication: 18 June 2022 6546 Caregivers burnout of their children with thalassemia Eman Al-sayed Haroon Al-sayed Demonstrator of Community health nursing-Faculty of Nursing, Al-fayoum University Dr. Sahar Ahmad Shafik Professor of Community Health Nursing- Faculty of Nursing, Al-fayoum University. National University of Science and Technology, Iraq Corresponding author email: Dsahar100@yahoo.com Dr. Amany Abdel Aziz Gomaa Assistant professor of Community Health Nursing- Faculty of Nursing, Al-fayoum University Dr. Ons Said El-Zayat Assistant professor of Community Health Nursing- Faculty of Nursing, Helwan University Abstract---Background: Thalassemia has a negative influence on emotional and social life of caregivers as it is associated with significant social disruption, emotional or psychological stress and highly involved with children's psychological problems. Aim: The study aimed to assess caregivers` burnout of their children with thalassemia. Design: Descriptive research design was applied in this study. Sample: Purposive sample was equal 116 caregivers. Setting: The outpatient clinics at Mustafa Hassan university hospital for pediatric (Al-fayoum, Egypt). Tools: Two tools were used, first tool: includes structure interviewing questionnaire of demographic characteristics of caregivers and their children, past and present medical history and caregivers` knowledge regarding thalassemia. Second tool: caregivers` burnout tool for thalassemia Result: The study showed that, 60% of studied caregivers had unsatisfactory knowledge regarding thalassemia while, 40% of them had satisfactory knowledge regarding thalassemia. 70% of studied caregivers had high burnout while, 30% of them had low burnout regarding thalassemia. Conclusion: there were significant positive correlation between studied caregivers’ total knowledge scores and total burnout scores of their children with thalassemia. Recommendation: implementation of