Shilpa A. Deshpande et al., Int. J. Res. Pharm. Sci., 2020, 11 (SPL4), 1473-1479 RĊěĎĊĜ AėęĎĈđĊ IēęĊėēĆęĎĔēĆđ JĔĚėēĆđ Ĕċ RĊĘĊĆėĈč Ďē PčĆėĒĆĈĊĚęĎĈĆđ SĈĎĊēĈĊĘ Published by JK Welfare & Pharmascope Foundation Journal Home Page: www.pharmascope.org/ijrps Resveratrol: A Pleiotropic Phytoconstituent Prashant N. Amale 1 , Manish P. Deshmukh 2 , Ashish B. Budhrani 3 , Shilpa A. Deshpande *1 1 Department of Pharmacology, Priyadarshini J. L College of Pharmacy, MIDC, Electronic Zone Building, Hingna Road, Nagpur, Pin-440016, Maharashtra, India 2 Department of Pharmacology, Jawarharlal Nehru Medical College, Datta Meghe College of Pharmacy, Datta Meghe Institute of Medical Sciences (DU), Wardha, Pin-442001, Maharashtra, India 3 Department of Pharmaceutics, Datta Meghe College of Pharmacy, Datta Meghe Institute of Medical Sciences (DU), Wardha, Pin-442001, Maharashtra, India Article History: Received on: 31 Jul 2020 Revised on: 23 Aug 2020 Accepted on: 02 Sep 2020 Keywords: Resveratrol, Pleiotropic, phytoconstituents, pain, inϐlammation AćĘęėĆĈę Resveratrol (RSV) is a plant polyphenol or phytolexin phytoconstituents obtained from the grapes, berries, peanut, and wine. RSV is obtained from natural source and regarded as safe, effective, and hepatoprotective drug with no other serious organ toxicities are reported yet. This property of RSV makes it advantageous over the allopathic medicine having symptomatic cure and plethora of adverse effects. It’s a cheap and widely available phy- toconstituent approved in the global market in the active form as trans- resveratrol. It has multiple pharmacological actions including, analgesic, anti-inϐlammatory, anti-anxiety, anti-parkinsonian, anti-alzheimers, antioxi- dant, antidepressant, anti-cancer, anti-diabetic, anti-atherosclerotic effects. These effects are mediated via modulation of diverse underlying endoge- nous molecules like reactive oxygen species, nitric oxide, malonaldehyde, neu- trophil, sirtulin, cyclo-oxygenase, inducible nitric oxide syntheses, superoxide dismutase, catalase, glutathione s-transferase, alpha-secretase, metallopro- teinases, C-reactive protein, dopamine, nor-adrenaline, serotonin, cytokines (interleukins), nuclear factor kappa, signal transducer activator of transcrip- tion, brain derived neural nactor, neuropeptide, hypothalamo-pitutary axis, astroglia, mitochondrial dysfunction, glutamate, adrenergic, cholinergic, opi- oidergic, and purinergic receptors. Researchers are trying to explore its addi- tional health beneϐits and preparing new analogues for better survival in the ϐield. Present review will help to enlighten the multi-target pleiotropic phar- macological nature of a RSV in relation to the variety of the molecular targets modulation through extensive web science literature survey. * Corresponding Author Name: Shilpa A. Deshpande Phone: +91-9422443171 Email: Shilpa@hotmail.co.in ISSN: 0975-7538 DOI: https://doi.org/10.26452/ijrps.v11iSPL4.4325 Production and Hosted by Pharmascope.org © 2020 | All rights reserved. INTRODUCTION Resveratrol (RSV) is a polyphenol, abundantly found in grape (skin and seeds), berries, peanuts and wine. This compound has many properties, includ- ing activity against glycation, immune response, oxidative stress, inϐlammation, neurodegeneration, several types of cancer, and aging (Kataria and Khatkar, 2019). RSV is well tolerated phyto- constituent and believed to be a promising com- pound in preventing many diseases, like depression, diabetes, asthma and other complications (Chen © International Journal of Research in Pharmaceutical Sciences 1473