Bansal SK et al. Biochemical changes in OSMF 101 Review Article Biochemical changes in OSMF Sanjiv Kumar Bansal, Swati Leekha 1 , Deeksha Puri 2 Department of Biochemistry, SGT Medical College, Hospital and Research Institute, Gurgaon. 1 Department of Oral Pathology and Microbiology, Swami Devi Dyal Hospital and Dental College, Panchkula, Haryana, 2 Medical Officer Kalomajra, Patiala, India. Corresponding Author: Dr. Sanjiv Kumar Bansal Department of Biochemistry SGT Medical College, Budhera, Gurgaon, Haryana India. Ph: +91 9814278407 Email:drsanjivbansal@rediffmail.com Received: 01-08-2013 Revised: 26-09-2013 Accepted: 08-10-2013 This article may be cited as: Bansal SK, Leekha S. Biochemical changes in OSMF. J Adv Med Dent Scie 2013;1(2):101-105. Introduction Oral diseases and conditions have a broad impact on health and well being of an individual. Since time immemorial, the teeth, the mouth, and the face have held a seemingly interesting fascination for mankind. 1 The mouth is the gateway to many diseases. Dental and medical practitioners encounter a wide spectrum of oral mucosal lesions in their day to day clinical practice. These mucosal lesions vary in nature from simple to life threatening ones. Inspite of the vast knowledge about mucosal lesions still there arises some controversies regarding some of the facts and certain aspects of the diseases are still questionable and need to be enlightened. Some of the common diseases under this category are Recurrent Aphthous Stomatitis, Lichen Planus, Oral Submucous Fibrosis and still more. “Oral Submucous Fibrosis” is one of the prevalent premalignant conditions in Asian countries which are easy to diagnose but difficult to manage. OSMF is an insidious chronic disease affecting any Abstract: OSMF is a chronic disease of the oral cavity, which is characterized by an epithelial and sub epithelial inflammatory reaction, followed by fibroelastic changes in the submucosa. Around 7-12% of oral submucous fibrosis cases undergo malignant transformation. Early detection of these lesions can drastically improve the treatment outcomes and prognosis in such patients. Carcinoma development is an intricate complex mechanism and the multifactorial causation makes it more difficult to find specific prognostic and therapeutic biomarkers. Thus, the development of newer diagnostic and predictive approaches that are less invasive, economical, and amenable to repeated sampling is imperative. This article discusses various biochemical changes in OSMF which signifies the early step of a condition towards malignant transformation. Key words: Submucous fibrosis, Biochemical, Oral disease.