267267 Aurea Mª Oliveira y col, BMI-2011; 1.3.4 (267-270) OA 267 Relation of insuline resistance in metabolic syndrome components to levels of HOMA-IR and HOMA-AD Aurea Maria Oliveira da Silva 1 , Mara P.T. Chacón-Mikhail 2 , Marcos Tambascia 1 , Andreia Gulak 2 , José Rocha 1 , Bruno Geloneze 1 , Ilka de Fátima Santana Ferreira Boin 1 1 Faculdade de Ciências Médicas, 2 Faculdade de Educação Física Universidade Estadual de Campinas- UNICAMP. SP. Brasil Received 2011.05.20 Accepted 2011.07.16 Summary: HOMA-IR is a mathematical model that predicts insulin sensitivity by measuring the blood glucose and fasting insulin. Adiponectin is an adipocytokine with anti- inflammatory function, anti-atherogenic, insulin sensitizing and anti-platelet and can be a HOMA sensitive predictor. This study compared these indices and verified the effectiveness of HOMA-IR and HOMA-AD. Methods: One hundred and fifty- six healthy volunteers aged 48.7 ± 6.0 years were studied in relation to liver function, anthropometric parameters and HOMA-IR and HOMA-AD. Aurea Maria Oliveira da Silva Aurea Maria Oliveira da Silva Rua Nelson Alaite, Rua Nelson Alaite, 71 apto 12 T 1 71 apto 12 T 1 Mansões Sto Antonio Mansões Sto Antonio Campinas Campinas- SP SP- Brasil Brasil- 13087 13087- 502 502 amos@unicamp.br amos@unicamp.br Results: Both HOMA-IR and HOMA-AD were positively correlated to ALT level but HOMA-IR was only correlated to GGT. HOMA-AD was positively correlated to the parameters: total cholesterol, HDL cholesterol and glycated hemoglobin. HOMA-IR with total cholesterol, triglycerides, HDL cholesterol and glycated hemoglobin were correlated positively. HOMA-IR and HOMA-AD correlated to both systolic and diastolic blood pressure. Conclusion: HOMA-AD was less effective than HOMA-IR. The association with HOMA was an excellent choice to establish an index of insulin resistance which can also predict cardiovascular risk since adiponectin has an effect on the atherogenesis blockade, for being lipid lowering and inversely related to BMI and visceral fat. Keywords: HOMA-IR, HOMA-AD, insulin resistance, metabolic syndrome. Introduction HOMA-IR (Homeostatic Assessment Index) is a mathematical model that predicts insulin sensitivity, measured by fasting blood glucose and basal insulin. It is strongly correlated to the hyper insulinemic-euglycemic clamp, the gold standard for assessing insulin resistance (IR) [1] and validated for the Brazilian population 2 . It is correlated positively to components of metabolic syndrome such as central obesity, lipid abnormalities, hypertension and atherosclerosis. Matsuhisa [2] used a new index, adapting HOMA (fasting glucose x fasting insulin). HOMA-IR was calculated from the product of serum insulin and plasma glucose levels divided by serum adiponectin levels (HOMA-AD). Adiponectin is an adipocytokine with anti- inflammatory function, anti- atherogenic, anti-platelet and insulin sensitizing. It is also the most abundant protein in serum insulin signaling pathways in muscle and liver and can be a sensitive predictor of HOMA. Individuals in the aging process physiologically accumulate larger amounts of truncal fat promoting the development of metabolic syndrome and thus increasing cardiovascular risk [3,4]. In this population, prevailing lower levels of adiponectin favored an increase in glucose and lipid levels and consequently insulin resistance. When comparing the two indices to the other components of metabolic syndrome, in middle age it can be possible to define the more appropriate for each variable. Age is associated with negative nitrogen balance due to sarcopenia. In this population, physical activity can be a benefit increasing protein synthesis and improving fat mass control. The objective of this study was to compare the two indices, HOMA-IR and HOMA- AD, correlating them with lipid variables, anthropometric parameters and liver enzymes in individuals as they age. Material and Methods Were studied 156 healthy volunteers with mean age 48.7 ± 6.0; other parameters may be seen in Table 1. Patients were selected