MOL #87312 1 CONNECTIVE TISSUE GROWTH FACTOR / CCN2 ATTENUATES β-ADRENERGIC RECEPTOR RESPONSIVENESS AND CARDIOTOXICITY BY INDUCTION OF G PROTEIN-COUPLED RECEPTOR KINASE-5 (GRK5) IN CARDIOMYOCYTES Jørgen Gravning, M. Shakil Ahmed, Eirik Qvigstad, Kurt Krobert, Thor Edvardsen, Ingvild Tronstad Moe, Else Marie V. Hagelin, Julia Sagave, Guro Valen, Finn Olav Levy, Jan-Bjørn Osnes, Tor Skomedal and Håvard Attramadal Institute for Surgical Research (J.G., M.S.A., I.T.M, E.M.V.H., H.A.) and Dept. of Cardiology (H.A., T.E.), Oslo University Hospital and University of Oslo, Oslo, Norway; Dept. of Pharmacology (E.Q., K.K., F.O.L., J.B.O., T.S.), University of Oslo and Oslo University Hospital, Oslo, Norway; Center for Heart Failure Research (J.G., M.S.A., E.Q., K.K., T.E., I.T.M., E.M.V.H., G.V., F.O.L., J.B.O., T.S., H.A.), K.G. Jebsen Cardiac Research Centre (E.Q., K.K., F.O.L., J.B.O., T.S.), and Dept. of Physiology (J.S., G.V.), University of Oslo, Oslo, Norway Molecular Pharmacology Fast Forward. Published on June 18, 2013 as doi:10.1124/mol.113.087312 Copyright 2013 by the American Society for Pharmacology and Experimental Therapeutics. This article has not been copyedited and formatted. The final version may differ from this version. Molecular Pharmacology Fast Forward. Published on June 18, 2013 as DOI: 10.1124/mol.113.087312 at ASPET Journals on February 17, 2022 molpharm.aspetjournals.org Downloaded from