Accepted Article Experiences in Microarray-based Evaluation of Developmental Disabilities and Congenital Anomalies Berk Ozyilmaz Ozgür Kirbiyik Altug Koc Taha Resid Ozdemir Ozge Ozer Kaya Merve Saka Guvenc Kadri Murat Erdoğan Yasar Bekir Kutbay Department of Medical Genetics, Izmir Tepecik Education and Research Hospital, Yenisehir, 35120, Izmir, Turkey. Acknowledgements We are most grateful to all our clinical colleagues and all our laboratory staff. No disclosures are reported. Conflict of Interest The authors whose names are listed above, certify that they have NO affiliations with or involvement in any organization or entity with any financial or non-financial interest in the subject matter or materials discussed in this manuscript. Ethical Statement The study was not submitted to a research ethics committee. ABSTRACT Chromosomal microarray analysis is the as first-tier test for the evaluation of developmental disabilities and congenital anomalies. In this report, we present CMA results of 971 patient and 301 parent samples. Among 971 patient samples, 133 (13,6%) had pathogenic variants. While analyzing, an “in-house” variant database was also used besides other databases. Owing to this, we have found chance to report the most frequent benign variants in Turkish population. With the additional data we acqured in this study, we also emphasized the high potential of CMA in revealing single gene disorders and novel gene-phenotype associations as well as copy number variations. This article is protected by copyright. All rights reserved. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/cge.12978