Vol.:(0123456789) 1 3 Arch Gynecol Obstet DOI 10.1007/s00404-017-4578-3 GYNECOLOGIC ENDOCRINOLOGY AND REPRODUCTIVE MEDICINE The role of serum ADAMTS‑1 and aggrecan on polycystic ovary syndrome in adolescents and younger‑aged females Esra Nur Tola 1  · Nadiye Dugan Koroglu 2  · Serenat Eris Yalcin 1  · Hilmi Baha Oral 1   Received: 4 April 2017 / Accepted: 24 October 2017 © Springer-Verlag GmbH Germany 2017 the development of CVD risk and IR was found among all patients. Serum ADAMTS-1 and aggrecan levels were sig- nifcantly and positively correlated with each other. Conclusion Increased levels of ADAMTS-1 could be a potential marker for the etiopathogenesis of PCOS in adoles- cents and younger-aged females and predict the development of CVD risk and IR among all patients with the same age. Keywords ADAMTS-1 · Aggrecan · PCOS · Adolescent · Younger-aged female Introduction Polycystic ovary syndrome (PCOS) is a well-known cause of anovulation afecting 6–26% of women of reproductive age [1]. It is clinically manifested as reproductive and metabolic abnormalities including hyperandrogenism, oligo-anovula- tion, and insulin resistance (IR) [2]. PCOS also has impor- tant long-term health problems such as obesity, type 2 diabe- tes, and cardiovascular disease (CVD) [2]. Most of the signs appear in adolescence and early adulthood in many PCOS patients [3]. Therefore, the early diagnosis and treatment are important for preventing the progression of PCOS. Impaired folliculogenesis resulting in the lack of development of a dominant follicle and ovulation are central in PCOS patho- physiology [4]. However, the exact mechanisms have yet to be determined. Thus, it is important to determine the under- lying etiopathogenetic factors causing PCOS to prevent the development of the disease. Continuous and extensive degradation and regeneration of the extracellular matrix (ECM) of ovarian tissue by matrix metalloproteinases, called tissue remodeling, is an essen- tial and highly regulated process for maintaining ovarian function [5, 6]. Although several investigations have been Abstract Purpose The aim of this study was to analyze serum a disintegrin-like and metalloproteinase with thrombos- pondin-type motifs-1 (ADAMTS-1) and aggrecan levels in adolescents and younger-aged females with polycystic ovary syndrome (PCOS) compared with ovulatory con- trols to determine whether these are potential markers for the prediction of PCOS diagnosis. We also aimed to deter- mine whether they could predict the development of clinical implications associated with PCOS. Method PCOS (n = 49) and ovulatory age-matched con- trols (n = 41) (mean age, 18.6 ± 2.5) were recruited. Anthro- pometric measurements were recorded and biochemical parameters were analyzed. Serum ADAMTS-1 and aggrecan levels were determined with enzyme-linked immunosorbent assay. The predictive efects of ADAMTS-1 and aggrecan on the diagnosis of PCOS and for the development of cardio- vascular disease (CVD) risk and insulin resistance (IR) were evaluated. The correlation between investigated markers and anthropometric, biochemical, and hormonal parameters were also investigated. Results Mean serum ADAMTS-1 level was increased in adolescents and younger-aged females with PCOS com- pared to ovulatory controls. An elevated ADAMTS-1 level was positive predictive of the diagnosis of PCOS with the best cut-of value of 2.5 ng/ml (sensitivity 69% and speci- fcity 78%). A positive predictive role of ADAMTS-1 on * Esra Nur Tola perinatalog@hotmail.com 1 Department of Gynecology and Obstetrics, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey 2 Department of Gynecology and Obstetrics, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey