This article is protected by copyright. All rights reserved Review Article Intricate Functions of Matrix Metalloproteinases in Physiological and Pathological conditions † Running title: Role of MMPs in health and disease Rahul Mittal *1 , Amit P. Patel * , Luca H. Debs * , Desiree Nguyen * , Kunal Patel * , M’hamed Grati * , Jeenu Mittal * , Denise Yan * , Prem Chapagain†‡ and Xue Zhong Liu*§ 1 * Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida †Department of Physics, Florida International University, Miami, Florida ‡Biomolecular Science Institute, Florida International University, Miami, Florida §Department of Biochemistry, University of Miami Miller School of Medicine, Miami, Florida 1 Corresponding Authors: Xue Zhong Liu, Ph.D., M.D., FACS Department of Otolaryngology, University of Miami-Miller School of Medicine, 1601 NW 12th Avenue, Miami, Florida 33136 Tel: 305-243-4923 305-243-1484 Fax: 305-243-2009 E-mail: xliu@med.miami.edu and Rahul Mittal, Ph.D. Department of Otolaryngology, University of Miami-Miller School of Medicine, 1601 NW 12th Avenue, Miami, Florida 33136 Tel: 305-243-4923 Fax: 305-243-4925 E-mail: r.mittal11@med.miami.edu Contract grant sponsor: National Institute on Deafness and Other Communication Disorders; Contract grant numbers: R01-DC05575, R01-DC01246 and R01-DC012115. † This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: [10.1002/jcp.25430] Received 12 May 2016; Accepted 16 May 2016 Journal of Cellular Physiology This article is protected by copyright. All rights reserved DOI 10.1002/jcp.25430 Accepted Article