Author’s Accepted Manuscript Intracellular labile iron determines H 2 O 2 -induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis M.D. Mantzaris, S. Bellou, V. Skiada, N. Kitsati, T. Fotsis, D. Galaris PII: S0891-5849(16)30322-7 DOI: http://dx.doi.org/10.1016/j.freeradbiomed.2016.07.002 Reference: FRB12925 To appear in: Free Radical Biology and Medicine Received date: 31 March 2016 Revised date: 15 June 2016 Accepted date: 4 July 2016 Cite this article as: M.D. Mantzaris, S. Bellou, V. Skiada, N. Kitsati, T. Fotsis and D. Galaris, Intracellular labile iron determines H 2 O 2 -induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis, Free Radical Biology and Medicine, http://dx.doi.org/10.1016/j.freeradbiomed.2016.07.002 This is a PDF file of an unedited manuscript that has been accepted fo publication. As a service to our customers we are providing this early version o the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain www.elsevier.com