Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2017, 9(4):185-190 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 185 One Pot Synthesis and Characterization of Some New 1,3,5-Trisubstituted Pyrazoline Derivatives Farouq E Hawaiz 1 , Lana H Chawishli 1 , Mohammed K Samad 1 and Shaaban K Mohamed 2* 1 Department of Chemistry, College of Education, University of Salahaddin-Hawler, Erbil 44001, Kurdistan Region, Iraq 2 Chemistry and Environmental Division, Manchester Metropolitan University, Manchester, M1 5GD, England _____________________________________________________________________________ ABSTRACT 1,3,5-trisubstituted pyrazoline derivatives containing both azo-linkages and benzyloxy moieties have been synthesized via one-pot three-component condensation reaction in high yields and short reaction process. The structures of the synthesized compounds were characterized by using FT-IR, 1 H-NMR, 13 C-NMR and 13 C- DEPT 135 spectra. Keywords: One-pot synthesis; Benzylation; Diazotization; Chalcones; Pyrazolines _____________________________________________________________________________ INTRODUCTION Synthesis of newly chemical compounds via a one pot reaction technique is broadly considered to improve the competency of chemical reactions in synthetic organic chemistry, whereby a mixture of reactive materials (three or more components) interact in a single reactor are undergoing successive chemical reactions to produce the target product [1]. There are several terminologies to describe multi-step reactions that take place in one pot such as “domino reaction”, “cascade reaction” [2,3], and “tandem reaction” [4,5], but the concept of one pot synthesis is still the most common applicable term as it reflects much wider meaning. This protocol is a very useful tool for organic chemists in industrially and medicinal purposes due to its economic impact. It shortened considerably the reaction time by reducing the number of synthetic steps, avoiding a long purification process, minimizing the waste of solvents and the separation stages of the intermediate chemicals [6]. Besides, it increases the proportion of products output [7]. Although this approach has firstly been employed since 100 years ago when Robinson [8] has reported his one-pot synthesis of tropinone, but it still has not received much of interest. Later on, among many other classic examples, one-pot reactions have been elegantly utilized in the biomimetic syntheses of progesterone by Johnson [9] endiandric acid by Nicolaou, [10-12] and proto- daphniphylline by Heathcock [13]. Over last two decades with the introduction of high-throughput biological screening, the importance of one pot synthesis for drug discovery has been recognized and considerable efforts from both academic and industrial researchers have been focussed especially on the design and development of single-pot methodology for the generation of bio-active heterocyclic compounds. Recently, one pot synthesis technique considered as a good protocol for green chemistry approach and the environmentally friendly applications compared to the conventional methods. Pyrazolines and azopyrazloine scaffold compounds are medicinally very important class of heterocyclic compounds due to their diverse of biological activities. They exhibited as anti-cancer [14], anti-fungal [15], Anti-convulsant [16] anti-inflammatory [17], analgesic [18], anti-leishmanial [19], anti-oxidant [20] and other anti-microbial activities [21-23]. Based on such facts we get prompted to design and synthesis of di-substituted pyrazoline compounds utilizing the one-pot synthesis strategy. In this work, nine target molecule of 1,3,5- trisubstited prazoline derivatives containing azo-linkages and benzyloxy moieties were synthesized along with spectroscopic characterization through a one-pot three-component condensation reaction.