_____________________________________________________________________________________________________ *Corresponding author: Email: ekechiamadi@yahoo.com; Journal of Cancer and Tumor International 12(4): 1-5, 2022; Article no.JCTI.88870 ISSN: 2454-7360 A Case Report of Management of Multiple Peri-orbital Cysts (Eccrine Hidrocystoma) in a 35-Year Old Woman E. S. Amadi a,b,c* , M. N. Amaewhule a,b and C. Okejim b a Dermatology Unit, Department of Internal Medicine, Rivers State University, Nkpolu-Oroworukwo, Nigeria. b Rivers State University Teaching Hospital, Harley Street, Old GRA, Port Harcourt, Nigeria. c University of South Wales, United Kingdom. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JCTI/2022/v12i430182 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/88870 Received 02 May 2022 Accepted 07 July 2022 Published 28 July 2022 ABSTRACT Background: Hidrocystoma is a rare benign swelling(tumour) of sweat glands also known as the cystic form of hidroadenoma, cystadenomas, sudoriferous cysts, and Moll’s gland. It has no racial or sex predilection. Its rarity and site of occurrence makes its management challenging due to limitation in knowledge of making diagnosis, treatment, availability of drugs and interventions and aesthetic concerns. Presentation of Case: A 35 year old Nigerian woman from the Igbo ethnic group with tertiary level of education who presented to the dermatology outpatient clinic with a 10 year history of recurrent peri-orbital swelling associated with occasional pruritus. There was no history of similar lesion in any family member. Patient had resorted to self-medication and consulted different doctors prior to being referred to the dermatologist. Her physical examination was normal. She was also counselled about the disease and management options. She subsequently received seven sessions of the chemo-ablation using trichloroacetic acid (TCA) with remarkable improvement and has had no recurrence of lesions for the past 1 year. Conclusion: Hidrocystomas can be successfully treated in our environment. Case Study