Conclusion: Rising in BUN over 24h plays a role in the prediction of severity and local complications in acute pancreatitis. Haematocrit  44% on admission plays a role in the prediction of pancreatic necrosis. EP02A-055 THE ROLE OF EXTRA-PANCREATIC INFECTIONS IN THE PREDICTION OF SEVERITY AND LOCAL COMPLICATIONS IN ACUTE PANCREATITIS E. Pando, P. Alberti, L. Vidal, M. Adell Trape, C. Gomez, M. Caralt, L. Blanco, C. Dopazo, J. Balsells and R. Charco Hepato-Pancreato-biliary and Transplant Surgery, Hos- pital Universitario Vall d’Hebron, Universidad Autónoma de Barcelona, Spain Background: The aim of our study was to determine the predictive power of extra-pancreatic infections (EPI) for assessing severity and local complications in AP including infected pancreatic necrosis (IPN). Methods: Clinical data of 280 AP patients prospectively enroled were analysed. EPI analysed were bacteraemia, pneumonia, urinary tract infection and catheter line infec- tion. Severity outcomes assessed were persistent organ failure (POF), persistent multi-organ failure (PMOF), mortality, hospital stay and intensive care unit (ICU) admission. A comparison using APACHE-II>8 points was made. For local complications, 37 consecutive patients with acute necrotising pancreatitis (ANP) were enroled. IPN was defined as a positive culture after necrosectomy. The pre- dictive accuracy of EPI was measured using area-under- the-curve (AUC) reciever-operating characteristics. Results: Fifty one cases of EPI were found (18.2%). Bacteraemia showed the best accuracy in predicting significantly POF, ICU admission and hospital stay > 20 days (AUC 0.686, AUC 0.749, AUC 0.628 respectively) and also for local complications including IPN and need for an interventinal procedure against necrosis (AUC 0.77, AUC 0.763 respectively) compared with pneumonia or APACHE-II>8 points. Bacteraemia was present in 9/15 cases of IPN, and preceded IPN in 6 cases. On the other hand pneumonia shows a good accuracy for dead and PMOF (AUC: 0.674 and AUC: 0.680). Conclusion: In our study, EPI, particularly bacteraemia, played a role in predicting severity and local complications in AP. EP02A-056 ARE PROCALCITONIN LEVELS ON ADMISSION RELATED TO ACUTE PANCREATITIS SEVERITY AND LOCAL COMPLICATIONS? M. Adell Trape, P. Alberti, C. Dopazo, E. Pando, L. Vidal, J. N. Hidalgo, L. Blanco, M. Caralt, J. Balsells and R. Charco Hepato-Pancreato-Biliary and Transplant Surgery, Hos- pital Universitario Vall d’Hebron, Universidad Autónoma de Barcelona, Spain Background: The aim of our study was to determine whether a cut-off level of procalcitonin (PCT) greater or equal than 2ng/ml at admission (during the first 72 hours after symptoms onset) could relate with acute pancreatitis (AP) severity and local complications (need for an invasive procedure against necrosis/infected necrosis). Methods: Clinical data of 57 AP patients, enrolled pro- spectively at our institution were analyzed. PCT levels were dosed during the first 72 hours since symptomatic onset and patients underwent contrast-enhanced CT within the first week of symptom onset. Parameters evaluated were: local complications (pancreatic necrosis infection, need for invasive procedures against necrosis) and AP severity: persistent organ and multiorgan failure (POF, PMOF), admission to intensive care unit (ICU), PA severity ac- cording to the Atlanta Classification (AC) and mortality. In order to determine statistical significance, Pearson’s chi- squared test and Fisher’s exact test were used. Results: There was no significant relation between PCT levels 2ng/ml and mortality, POF, PMOF, ICU, prolonged hospitalization, AP severity according AC and the presence of pancreatic necrosis. PCT  2ng/ml had a significant statistical association for transient OF (72.7% vs 13%, p< 0,0005), antibiotics use (81.8% vs. 28.9%, p=0,001), need for an invasive procedures against necrosis (27.3% vs. 4.3% , p=0,045) and infected pancreatic necrosis (27.3% vs 2.2%, p=0.014). Conclusion: At admission, dosing PCT levels could help determine acute pancreatitis clinical course and the pres- ence of local complications, especially the need of invasive procedures against local complications. EP02A-057 EXTRAPANCREATIC NECROSIS WITH PANCREATIC (EXPN) INTRAPANCREATIC NECROSIS (INPN) PREDICTS SEVERITY AND LOCAL COMPLICATIONS IN ACUTE PANCREATITIS BETTER THAN ISOLATED EXPN OR INPN L. Vidal, E. Pando, C. Dopazo, P. Alberti, J. N. Hidalgo, C. Gomez, L. Blanco, M. Caralt, J. Balsells and R. Charco Hepato-Pancreato-Biliary and Transplant Surgery, Hos- pital Universitario Vall d’Hebron, Universidad Autónoma de Barcelona, Spain Background: In the course of acute necrotizing pancrea- titis the presence of extrapancreatic necrosis (EXPN) and its influence over the clinical course is not well define. Methods: Clinical data of 237 patients enrolled prospec- tively at our institution were analyzed. They underwent contrast-enhanced CT or RMN within the first week of symptom onset. Parameters evaluated were: local compli- cations (pancreatic necrosis infection, need for invasive procedures against necrosis) and AP severity (persistent organ and multiorgan failure (POF, MOF), admission to intensive care unit (ICU), PA severity according to the Atlanta Classification) and mortality. EXPN and its asso- ciation with intrapancreatic necrosis (INPN) were analysed. Area-under-the-curve receiver-operating characteristics (AUC) were applied. Results: The ocurrence of EXPN with INPN showed su- periority over the isolated presentation of EXPN or INP for POF (AUC:0.648, p=0.004), MOF (AUC:0.69, p=0.003) mortality (AUC: 0.682, p=0.022), ICU (AUC:0.656, HPB 2018, 20 (S2), S505eS684 Electronic Posters (EP02A-EP02F) e Pancreas S521