International Journal of Health Sciences and Research Vol.12; Issue: 6; June 2022 Website: www.ijhsr.org Original Research Article ISSN: 2249-9571 International Journal of Health Sciences and Research (www.ijhsr.org) 214 Vol.12; Issue: 6; June 2022 Clinical and Etiological Profile of Ischemic Stroke in a Tertiary Care Hospital of Nepal Krishna Kumar Yadav 1 , Rajesh Kumar Mandal 2 1 Consultant Physician, Department of Internal Medicine, Provincial Hospital, Madhesh Province, Janakpurdham, Nepal 2 Consultant Physician, Department of Internal Medicine, Bheri Hospital, Nepalgunj, Nepal Corresponding Author: Dr. Krishna Kumar Yadav DOI: https://doi.org/10.52403/ijhsr.20220628 ABSTRACT Background: Stroke is one of the most common neurological diseases, often leading to disability and death. Ischemic stroke accounts for 80-85% of all stroke cases. This Study aimed to evaluate the clinical and etiological profile of patients of ischemic cerebrovascular stroke. Materials and Methods: This was a cross sectional, observational study of 93 patients of ischemic cerebrovascular stroke, conducted at Bir Hospital, Kathmandu during January 2018 to December 2019. The patients detailed history, examinations, blood investigation, CT Scan head and Echocardiography was done. The data were recorded in Excel a sheet and analyzed by SPSS 20. Results: The mean age of ischemic stroke patients was 63.28 +_ 15.52 with a range from 30 to 94 years. The stroke was predominant in male with 52(55.91 %). The most common risk factors for stroke were hypertension 54(58.06%), followed by smoking 48(51.61%), LVH 45(48.38%), hypercholesterolemia 26(27.95%), diabetes mellitus 11(11.82%), atrial fibrillation 3(3.22%) and coronary artery disease 1(1.07%). Hemiplegia was present in all the patients. Other common symptoms included dysarthria due to facial deviation in 73.11%, speech aphasia in 6.45 % and altered sensorium/loss of consciousness in 1.07 % patients. Conclusion: Stroke is not limited to elderly population; younger adults are also vulnerable for stroke. Hypertension, smoking, hypercholesterolemia, diabetes mellitus are common risk factors which can be modified for prevention of stroke. Keywords: Ischemic stroke; hemiplegia; risk factors. INTRODUCTION Strokes are considered to be one of the leading causes of death and physical disability worldwide. According to the World Health Organization, stroke is the second most common cause of deaths globally-a total of 5,781 million death. 1 The Jaya Stroke Foundation, established by Nepalese doctors and family members of stroke patients, estimates that each year approximately 50,000 people have stroke and 15,000 people die from stroke. 2 Socio economic factors, dietary and lifestyle choices, demographic transitions and different patterns of risk factors namely modifiable and non-modifiable explain the incidences of strokes to great lengths. 3 Stroke can be prevented by early modification of risk factors like hypertension, diabetes mellitus, dyslipi- demia, heart disease, atrial fibrillation, smoking, obesity and alcoholism. 4 A community survey from India revealed a crude prevalence rate of 200 per 1,00,000 persons for hemiplegia, nearly 1.5% of all urban hospital admissions, 4.5% of medical cases and around 20% of neurologic cases. 5 There is paucity of data