467 Available online at www.joac.info ISSN: 2278-1862 Journal of Applicable Chemistry, 2012, 1 (4):467-477 Synthesis and Utilization of Saccharin Derivatives Sushanta Maiti 1 , D.Rambabu 2 , ASG Prasad 2 , G.Venkata Rao 3 and Mandava V. Basaveswara Rao 4 * 1. Department of Chemistry, NIMS University, Rajastan, India. 2. Department of Chemistry, K L University, Vaddeswaram Guntur-522502, A. P, India. 3. Department of Bio-Chemistry, SRR & CVR Govt. College, Vijayawada, A. P, India. 4. Department of Chemistry, Krishna University Dr.MRAR PG Centre,Nuzvid-521201, A. P, India Email: professormandava@gmail.com Received on 05 th November and finalized on 07 th November 2012 ______________________________________________________________________________ ABSTRACT Saccharin derivatives could be readily prepared from inexpensive and readily available materials and used these derivatives for the organic transformations. These compounds were well characterized by spectral data (NMR, MS). Graphical Abstract SYNTHESIS AND UTILIZATION OF SACCHARIN DERIVATIVES Sushanta Maiti, D.Rambabu, ASG Prasad, G.Venkata Rao and Mandava V. Basaveswara Rao* Keywords: Saccharin, ethers, amines, aldehydes, alcohols. ______________________________________________________________________________ INTRODUCTION Saccharin,1,2-benzisothiazole-3-one-1,1-dioxide, is a well known heterocyclic compound and has been used as a sweetener in the form of its sodium salt since 1885. Yet it is also a heterocyclic molecule of pharmaceutical importance and one of the key structural element of certain CNS-active drugs[1]. Saccharin compounds have been intensively investigated due to its suspected cancerogenic nature[2]. Many biological activities have been attributed (International Peer Reviewed Journal)