Turkish Journal of Physiotherapy and Rehabilitation; 32(2) ISSN 2651-4451 | e-ISSN 2651-446X www.turkjphysiotherrehabil.org 1285 Review On Side-Effects Of Covid-19 In The Growth Of Neurologic Diseases SHOBHA T a , SEEMA PATIL b , DR. R CH. A. NAIDU c , DR. E SARAVANA KUMAR d AND K.VENGATESAN e a,b,d Associate Professor,Department of CSE,TOCE,Bangalore, affiliated to VTU, Belgaum c Professor & HOD, Department of CSE, TOCE,Bangalore, affiliated to VTU, Belgaum e Professor, Computer Engineering, Sanjivani College of Engineering, Kopargaon a t.shobha2020@gmail.com, b theseema@gmail.com, c chanr789@gmail.com, d saraninfo@gmail.com, e vengicse2005@gmail.com ABSTRACT Recent studies on risk factors and characteristics of the corona virus disease 2019 epidemic, have set up evidences that suggests persons afflicted by corona virus may suffer from neurological deficiency. Severely affected patients suffer from acute respiratory dysfunction, high levels of cytokines, immune response and neuroinflammation. These factors are the main causes for neurodegeneration that plays a vital role in Alzheimer Disease (AD). It is also said that the aged people are further vulnerable to AD after corona virus disease 2019 infection. This review gives the insight about risk factors of severely infected and elderly patients of COVID-19 developing cognitive decline, and gradually to AD, after recovering from SARS-CoV- 2 infection. The main intention behind this review is to provide the base on future studies and investigations on corona virus and its effects on the neuro system. And also, to provide the awareness among the caretakers of corona virus infected persons with AD. Keywords: Alzheimer’s, COVID-19, Cytokine, Inflammation, Neurodegeneration 1. INTRODUCTION In late 2019, the origin of novel corona virus had been tracked down to a market in Wuhan, China [1]. The Corona virus was declared as a global pandemic by the World Health Organization on March 11, 2020 [2]. WHO report dated 6 April 2021, states globally 131,309,792 confirmed cases of corona virus disease 2019, with 2,854,276. There are many observations that reported symptoms of Covid-19 that includes wide variety of neurological manifestations [4]. 36.4% incidence of neurological damage caused by corona virus has been reported in the retrospective study of 214 COVID-19 infected people. This shows the increasing evident of contribution of SARS-Cov-2 to a number of neurological issues which includes seizures, confusion, stroke, encephalopathy, anosmia, and total paralysis [5]. 1. BACKGROUND A recent study showed that 49 patients out of 58 admitted due to ARDS in ICU in Strasbourg in France, exhibited neurological symptoms during medical care, which includes confusion, agitation and signs of pyramidal tracts dysfunction such as enhanced tendon reflexes and clonus [27, 4]. 15 patients out of 45 had suffered from dysexecutive symptoms (for example heedlessness, confusion, or ineffectively composed movement in response to order), at discharge. 1.1. Symptoms of Covid-19 leading to Alsheimer’s disease There is a continuing high risk of enduring psychopathic and Organic brain syndrome conditions like parkinsonism, depression, psychosis, Alzheimer ’s and obsessive compulsive in the discharged patients from ICU