https://doi.org/10.31871/WJIR.12.2.21 World Journal of Innovative Research (WJIR) ISSN: 2454-8236, Volume-12, Issue-2, February 2022 Pages 28-32 28 www.wjir.org Abstract— Englerina drummondii Balle ex Polhill & Wiens commonly known as mistletoe is widely known and use for the treatment of various illments by the traditionalists in Africa. The aim of this study is to evaluate the effect of hydroalcohol extract of Englerina drummondii Balle ex Polhill & Wiens on biochemical parameters such as superoxide dismutase (SOD), malon dialdehyde (MDA), catalase, cholesterol and total protein following administration of mono sodium glutamate in female wistar rats. The results revealed that Superoxide dismutase (SOD) is significally increased in groups 5 and 9 when compared with control. control group and when the MSG 800mg/kg only group is compared with group 8, shows a significance decreased in SOD and when compared with group 9, it shows a significance increased in SOD. Catalase (CAT) shows a significance decreased in groups 2, 4, 5, 8, and 9 when compared with control group and shows significance increased in group 7 and when the MSG 800mg/kg only group is compared with groups 1, 6, and 7, it shows a significance increased in CAT and groups 4, 8, and 9 shows a significance decreased in CAT. Malon dialdehyde: When normal control group is compared with groups 2, 3, 4, 6, 7, 8, and 9 shows a significance increased in MDA and group 5 shows a significance decreased in MDA. Also, when MSG 800mg only group is Gbaranor K.B., Department of Human Physiology, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria. Mube W. A., Department of Obstetrics and Gynaecology, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria Sapira-Ordu L., Department of Obstetrics and Gynaecology, Rivers State University Teaching Hospital, Port Harcourt, Nigeria Mbooh D. N., Department of Obstetrics and Gynaecology, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria Tomii B. C., Department of Laboratory Access Programme, CHAI Nigeria Daka I. R., Department of Pharmacology and Therapeutics, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria Nonju I. I, Department of Human Physiology, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria. Austin-Asomeji I., Department of Community Medicine, Rivers State UniversityTeaching Hospital, Port Harcourt, Nigeria Oriji E. I., Department of Human Physiology, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria. George B. O., Department of Medical Biochemistry, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria. Enebeli S. K., Department of Pharmacology and Therapeutics, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria Bademosi A., Department of Community Medicine, Rivers State UniversityTeaching Hospital, Port Harcourt, Nigeria Nonju T. I., Department of Pharmacology and Therapeutics, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria compared with groups 1, 3, 4, 5, 6, 7, 8, and 9 shows a significance decreased in MDA. Total protein: When normal control group is compared with group 9 there is a significance increased in total protein and when MSG 800mg only group is compared with group 7 there is a decreased in total protein. Total cholesterol: When normal control group is compared with groups 4, 5, 7, and 9 shows a significance increased in total cholesterol and when MSG 800mg only group is compared with group 4 shows a significance increased in total cholesterol. Index Terms— Englerina drummondii Balle ex Polhill & Wiens, Oxidative Stress, Indicators, Catalase, Total Cholesterol I. INTRODUCTION Englerina drummondii Balle ex Polhill & Wiens commonly known as mistletoe is widely known and use for the treatment of various illments by the traditionalists in Africa. The plant Englerina drummomdii Balle ex Polhill & Wiens is commonly called mistletoe that belongs to a large family called loranthacae. Englerina drummomdii Balle ex Polhill & Wiens is a parasitice plants that bear green leaves and fruits. It is commonly called Atabe by the people of Khana in Ogoniland, Niger Delta, Nigeria (Gbaranor et al.2021). Several plants have been used across the globe by traditionalists for the treatment of various diseases without proper documentation especially in Africa (Gbaranor et al.2021). Phytomedicine involves the use of various plant’s parts such as leaves, stems, seeds, fruits, barks and roots to treat certain disease at home. Different plants show different phytochemical constituent while some shows similar phytochemical constituents (Gbaranor et al.2021). There is presence of stress at all level in every human society which could come as social, physical and psychological stress (Sharma et al, 2013). Life-style parameters like “psychological stress, cigarette smoking, alcohol consumption, environmental and occupational exposures affect reproductive health of a female” according to Sharma et al (2013). Oxidative stress results from an imbalance between production and accumulation of oxygen reactive species (ROS) in cells and tissues and the ability of a biological system to detoxify these reactive products (Gabriele Pizzino, et al, 2017). Reactive oxygen species (ROS) production, therefore causing the imbalance that leads Effects of Hydro-Alcohol Extract of Englerina Drummondii Balleex Polhil & Wiens Leaves and Msg on Oxidative Stress Indicators (SOD, MDA) and Catalase, Total Cholesterol and Protein in Ovaria Tissues of Female Rats Gbaranor K.B., Mube W. A., Sapira-Ordu L., Mbooh D. N.,Tomii B. C., Daka I. R.,Nonju I. I, Austin-Asomeji I., Oriji E. I.,George B. O., Enebeli S. K.,Bademosi A., Nonju T. I.