Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2018, 10(6): 1-6 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 1 A Synthetic Approach on ZnO Quantum Dot G Sivasankari 1* , E Sundharavadivel 2 , S Boobalan 3 , A Sharmila 1 and C Rasikavinothini 1 1 Department of Chemistry, Cauvery College for Women, Thiruchirapalli, Tamil Nadu, India 2 Department of Chemistry, SRM University, Chennai, India 3 Department of Chemistry, VSB Engineering College, Karur, India _____________________________________________________________________________ ABSTRACT In recent existence, ZnO quantum dots (QD) have fascinated awareness as awfully hopeful candidates for optoelectronic, electronic, and biological applications. Low toxicity, low cost, and biocompatibility makes them excellent candidates for in vivo bio-imaging, gene/drug delivery and cancer detection. This QD have too promised momentous burst through an examine for sterile agents, and in exposure of imperative antigens and allergens because of their high isoeletric points. The ZnO Quantum dots were synthesized. The quantum dots are characterized by using UV-Visible spectroscopy, Fluorescence Spectrophotometer, X-ray diffraction studies, Transmission Electron Microscope and Electron dispersive spectroscopy are found to be having a particle in the range from 2 nm to 5 nm. This study shows that lowest grain size and highest band gap influences the optical properties by reducing the size. Due to excellent optical properties such as size tunable fluorescence and a narrow and symmetric emission profile a broad excitation range II-IV fluorescent Quantum dots have undergone intensive investigation as a new type of biolabling over a recent years and also proven to be superior to conventional dyes. The ease of processing and good photoluminescence property of ZnO quantum dots provides practical and economical approach signal-target imaging application. Keywords: ZnO; Quantum dot; Synthesis; X-ray diffraction _____________________________________________________________________________ INTRODUCTION The integration of nanotechnology with biotechnology is an attractive trend as nanotechnology provides the analytical tools and platforms for the investigation of biological systems. As a powerful fluorescent probe, quantum dots have been used for imaging of biological targets, disease diagnoses and prognoses, tracking cell/protein interactions and cell vitality, etc. Traditional organic dyes are limited by their narrow excitation range, low fluorescence intensity and short lifetime. On the contrary, QDs have broad excitation but narrow, strong and tunable emission spectra [1-3]. Which allow the simultaneous observation of multiple probes with different fluorescent colors using a single light source [4], with bright emission and extraordinary photo stability [5]. QDs make the long- term real-time monitoring and tracking of molecules and cells more feasible. For example, researchers were able to observe QDs in lymph nodes of mice for more than 4 months [6]. The improved photo stability of quantum dots also allows the acquisition of many consecutive focal-plane images that can be reconstructed into a high-resolution three- dimensional image. Furthermore, QDs have the fluorescence lifetime significantly longer than that of organic dyes or auto-fluorescent flavin proteins [7]. Therefore, combined with pulsed laser and time-gated detection, the use of QDs label can produce images with greatly reduced background noise [8].