6 CYTOMEGALOVIRUS IgG AND IgM ANTIBODIES AMONG SUDANESE PATIENTS WITH ACUTE MYELOID LEUKEMIA: RELATION TO HEMATOLOGICAL PROGNOSTIC MARKERS Elamin O M AbuAlas 1 ; MD, Omar W.A. Mohamed 2 ; M.Sc, Mohammed FadlElmola Ahmed 3 ; M.Sc. WalaEldin O. Elradi 4 ; M.Sc, 1 Dep. of Microbiology, Faculty of Medicine, Sudan Internatonal University-Sudan 2 Dep. of Molecular Biology, Insttute of Endemic Disease (IEND), University of Khartoum, Sudan 3 Dep. of Hematology, Faculty of Medical Laboratory Sciences, Natonal Ribat University, Sudan 4 Dep. of Hematology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Sudan Original Article International Journal of Clinical and Biomedical Research. © 2017 Sumathi Publications. This is an Open Access article which permits unrestricted non-commercial use, provided the original work is properly cited. INTRODUCTION Acute myeloid leukemia myelogenous leukemia (AML) is a neoplastc disease of the myeloid hempoietc cells described by the accelerated growth of abnormal mye- loblasts that accumulate in the bone marrow and blood and may infltrate other organs. AML is the most com- mon acute leukemia afectng adults, and its incidence increases with age [1]. Viral oncogenesis has remained an area of interest in cancer biology. Viruses have been great tutors of cancer biology, helping researchers to uncouple many signaling pathways and identfying crit- cal therapeutc targets. With the advent of advanced molecular techniques, more viruses have been atribut- ed to cause neoplasms in humans [2]. The role of infectons in carcinogenesis is abundantly described. Human cytomegalovirus (HCMV) is a ubiqui- tous herpes virus that leads to a life-long persistence. The frequency of infecton ranges from 50% to 100% in the general adult populaton [3]. Human cytomegalovi- rus causes severe and ofen fatal disease in immuno- compromised individuals including recipients of organ Correspondence: Elamin O M AbuAlas, Dept. of Microbiology, Faculty of Medicine, Sudan International University-Sudan , Email: elaminabualas@gmail.com transplants and AIDS patents. It routnely reactvates in healthy virus carriers, but this is usually controlled by the host immune response. Monocytes may be an im- portant reservoir for latent HCMV; however, the prima- ry reservoir may be a more primitve cell from the mye- loid lineage. Reactvaton may result from cellular diferentaton or infammaton [3]. Resistance to apop- tosis is a mechanism of carcinogenesis and also way for resistance to chemotherapy by cancer cells. HCMV in- fecton was reported to protect fbroblasts from apop- tosis induced by adenovirus E1A protein. Moreover, the HCMV IE1-72 and IE2-86 proteins inhibited apoptosis induced by the adenovirus E1A and TNF-α and HCMV exerts its antapoptotc efects through IE proteins by both p53-independent and p53-dependent mechanism [4] . Few data is available for the incidence of CMV and its clinical impact in the prognosis of AML. The aims of the present study were to assess prospectvely the inci- dence of actve CMV infecton in Sudanese patents with AML and to describe the impact of CMV in prog- nosis of AML by the evidence of hematological prog- nostc markers (TWBC and blast count). METHODOLOGY Study design: Analytcal case control study Ethics approval: The study was approved by the IEC and Consents were obtained from the parents/ caregiv- ers of the subjects and controls afer explaining to them, in detail, the objectves of the study as well as ABSTRACT Background: Viral oncogenesis has remained an area of interest in cancer biology. Viruses have been great tutors of cancer biology, helping researchers to uncouple many signaling pathways and identfying critcal therapeutc targets. Aim: The aim of this study was to assess the incidence of cytomegalovirus (CMV) infecton and its impact on hemato- logical prognostc markers of Acute Myeloid Leukemia (AML) among Sudanese populatons. Method: The sero- prevlance of CMV infecton in AML patents was assessed in 100AML and 100 age and gender -matched controls. The associatons of total white cell count and absolute blast count with the seroprevlance were examined. Results: The prevalence of CMV infecton was 81% in patents and 17% in control subjects. Total white cell count and blast count were higher in AML CMV positve patents than AML CMV negatve patents. Conclusion: Our fndings indicate a high incidence of CMV infectons in AML and its worse associaton with hematological markers could emphasize the role of CMV in the progression of AML. KEYWORDS: Acute myeloid leukemia, Cytomegalovirus. DOI: 10.5455/ijcbr.2017.33.03 eISSN: 2395-0471 pISSN: 2521-0394 brought to you by CORE View metadata, citation and similar papers at core.ac.uk provided by Sumathi Publications (E-Journals)