Vol.:(0123456789) 1 3 Clinical and Translational Oncology https://doi.org/10.1007/s12094-019-02124-9 RESEARCH ARTICLE Survival outcomes in patients aged 75 years and over with peritoneal colorectal carcinomatosis after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC): multicenter study of the Spanish Group of Peritoneal Cancer Surgery (GECOP) P. A. Cascales‑Campos 1,2  · V. López‑López 1,2  · J. Torres‑Melero 3  · A. Arjona 4  · F. C. Muñoz‑Casares 4,5  · P. Barrios 6  · R. Morales 7  · F. Pereira 8  · P. Bretcha‑Boix 9  · L. González‑Bayón 10  · S. González‑Moreno 11  · J. Gil 1,2 Received: 26 March 2019 / Accepted: 19 April 2019 © Federación de Sociedades Españolas de Oncología (FESEO) 2019 Abstract Background The attitude toward cytoreductive surgery with HIPEC in peritoneal carcinomatosis from colorectal can- cer is unclear. The aim of this study is to report the perioperative outcomes after cytoreductive surgery with HIPEC in patients ≥ 75 years. Methods This retrospective multicenter study collected the data the Spanish Group of Peritoneal Cancer Surgery. Thirty-six patients with peritoneal carcinomatosis from colorectal cancer met the selection criteria for the study. Morbidity, mortality, disease-free and overall survival were analyzed. Results Morbidity (grade III–IV) was 17% and 2 patients died of complications related to the procedure (5.4%). Median disease-free survival (DFS) was 16 months. DFS at 1 and 3 years was 81% and 42%, respectively. Overall survival at 1 and 3 years was 96% and 75%. In the univariate analysis, preoperative comorbidities (p = 0.01), liver metastases (p = 0.02), blood transfusion (p = 0.001) and postoperative complications (p = 0.001); and in the multivariate analysis, perioperative blood transfusion (OR 2.56, 95% CI 1.95–6.24, p = 0.03) and postoperative complications (OR 3.25, 95% CI 2.35–7.56, p = 0.02) were associated with a lower overall survival. Conclusions Age is not an absolute contraindication to perform cytoreduction surgery with HIPEC in highly selected elderly patients with colorectal peritoneal carcinomatosis. Keywords Elderly · Colorectal carcinomatosis · HIPEC · Morbidity · Survival Introduction Colorectal cancer is one of the most frequent solid tumors in the Western world. Treatment options are dependent on disease stage, the performance status of the patient, and increasingly the molecular characteristics of the tumor. In countries with screening programs, the incidence rate as well as the mortality rate has gone down because of earlier tumor detection. * P. A. Cascales-Campos cascalescirugia@gmail.com 1 Hospital Clínico, Universitario Virgen De La Arrixaca, Carretera Madrid-Cartagena S/N, El Palmar, CP: 30120 Murcia, Spain 2 IMIB-Arrixaca, Murcia, Spain 3 Hospital Universitario De Torrecárdenas, Almería, Andalucia, Spain 4 Hospital Universitario Reina Sofía, Córdoba, Andalucia, Spain 5 Present Address: Hospital Universtiario Virgen del Rocio, Sevilla, Spain 6 Hospital De Sant Joan De Espi Moises Broggi, Sant Joan De Espi, Cataluña, Spain 7 Hospital Universitario Son Espases, Palma de Mayorca, Islas Baleares, Spain 8 Hospital Universitario De Fuenlabrada, Madrid, Spain 9 Hospital Quirón de Torrevieja, Alicante, Comunidad Valenciana, Spain 10 Hospital General Universitario Gregorio Marañón, Madrid, Spain 11 MD Anderson Cancer Center, Madrid, Spain