DOI: 10.4274/uob.534 Bulletin of Urooncology 2016;15:38-40 38 Retroperitoneal İnfamatuvar Miyofbroblastik Tümör: Olgu Sunumu ve Literatür Taraması Retroperitoneal Inflammatory Myofibroblastic Tumor: A Rare Case Report and Literature Review Address for Correspondence/Yaz›flma Adresi: Oktay Üçer MD, Celal Bayar University Faculty of Medicine, Department of Urology, Manisa, Turkey Phone.: +90 505 211 46 18 E-mail: uceroktay@yahoo.com Received/Geliş Tarihi: 27.11.2015 Accepted/Kabul Tarihi: 04.12.2015 © Bulletin of Urooncology, Published by Galenos Publishing. / © Üroonkoloji Bülteni, Galenos Yayınevi tarafından basılmıştır. 1 Celal Bayar University, Faculty of Medicine, Department of Urology, Manisa, Turkey 2 Celal Bayar University Faculty of Medicine, Department of Pathology, Manisa, Turkey Oktay Üçer MD 1 , Mehmet Yüksel MD 1 , Gökhan Temeltaş MD 1 , Peyker Temiz MD 2 , Talha Müezzinoğlu MD 1 Introduction The inflammatory myofibroblastic tumor (IMT), also known as inflammatory pseudotumor, is an uncommon tumor characterized by a controversial etiology, various histopathological features, and an unpredictable biological behavior (1). The profile of this disease has changed with time from benign reactive process to a malignant neoplasm, based on the multiple case reports demonstrating recurrent and constant clonal genetic alterations (2). There are three main histological patterns; nodular fasciitis- like, fibrous histiocytoma-like, and desmoid or scar tissue-type (3). IMT is usually diagnosed in adults in the lungs. It is also described in the other locations, such as the kidney, orbit, liver, pancreas, spleen mesentery and limbs and may also be seen during childhood (4). However, retroperitoneal location is rarely reported in literature. Case Report The patient is a 52-year old woman with a history of abdominal lump and complaint of exhaustion for two years, and with no history of urinary tract symptoms. She had no history of abdominal trauma, or urinary tract infection, but she underwnt umbilical hernia repair 5 years ago. Physical examination did not reveal any pathological findings. Blood count parameters were within normal limits except low hemoglobin rate (hemoglobin: 11.7). C-reactive protein and tumor markers were also negative. Contrast-enhanced computed tomography revealed an 84x78x106 mm mass on the right side, located inferior to the adrenal gland, and posterior to the kidney (Figure 1). It seemed to be separate from the kidney tissue. Tru-cut biopsy was performed; Histopathological examination revealed connective tissue infiltrated by T and B lymphocytes and enlarged vascular structures. There were no tumor cells seen Primary retroperitoneal inflammatory myofibroblastic tumors (IMT) are a very rare clinical condition. Herein, we present a case of IMT in the retroperitoneal area. A 52-year-old woman presented with abdominal lump and exhaustion. On physical examination, there was no pathological finding. The diagnostic workup included contrast computer tomography that revealed a 10,5-cm heterogeneous retroperitoneal mass under the right adrenal gland, localized behind the right kidney. At laparotomy, the mass arising from the retroperitoneum was excised. Histopathology showed an IMT. IMTs has a variable biologic behavior that ranges from the frequently benign lesions to more aggressive variants. Final diagnosis is based on histomorphological features. Complete surgical excision should be the aim of the curative treatment. Keywords: Retroperitoneum, myofibroblastic tumor, inflammatory myofibroblastic tumor Summary Primer retroperitoneal inflamatuvar miyofibroblastik tümörler (İMT) klinikte oldukça nadir görülür. Burada retroperitoneal alandaki İMT olgusu sunuldu. Elli iki yaşında kadın hasta batında kitle ve halsizlik şikayetleriyle başvurdu. Fizik muayenesinde patolojik bir bulgu saptanmadı. Kontrastlı bilgisayarlı tomografisinde retroperitonda sağ adrenal bezin altında ve böbreğin arkasında 10,5 cm çaplı heterojen kitle görüldü. Kitle cerrahi olarak eksize edildi ve patolojisi İMT geldi. İMT kötü huylu lezyonlardan daha agresif özellikler taşıyana kadar değişik şekillerde görülebilmektedir. Kesin tanı histopatolojik olarak konulmaktadır. Küratif tedavideki amaç kitlenin tam cerrahi eksizyonudur. Anahtar Kelimeler: Retroperiton, miyofibroblastik tümör, inflamatuvar miyofibroblastik tümör Öz Case Report / Olgu Sunumu