How to Cite: Aly, A. M. E., Nakeeb, M. M. E., Agameya , H. M., & Ghandour, M. A. M. (2022). Stroke volume versus stroke volume variations as guidance for fluid therapy in major abdominal surgery. International Journal of Health Sciences, 6(S6), 5403–5415. https://doi.org/10.53730/ijhs.v6nS6.10776 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2022. Manuscript submitted: 9 March 2022, Manuscript revised: 27 May 2022, Accepted for publication: 18 June 2022 5403 Stroke volume versus stroke volume variations as guidance for fluid therapy in major abdominal surgery Ahmed Mohamed Elsayed Aly Assistant Lecturer of Anaesthesia and Surgical Intensive Care, Faculty of Medicine, Alexandria University, Alexandria, Egypt *Corresponding author email: a_elsayed142@medalex.edu.eg Prof. Dr. Mohamed Mohamed El Nakeeb Professor of Anaesthesia and Surgical Intensive Care, Faculty of Medicine, Alexandria University, Alexandria, Egypt Prof. Dr. Hussein Mohamed Agameya Professor of Anaesthesia and Surgical Intensive Care, Faculty of Medicine, Alexandria University, Alexandria, Egypt Dr. Moutaz Abdel Mohsen Ghandour Lecturer in Anaesthesia and Surgical Intensive Care, Faculty of Medicine, Alexandria University, Alexandria, Egypt Abstract---Background: The aim of the present study was for comparison of stroke volume versus stroke volume variations as guidance for fluid management under guide directions of electrical cardiometry, during major abdominal surgeries. The primary outcome was to compare between two fluid infusion protocols, regarding the haemodynamic changes, whereas secondary outcomes were to evaluate the impact of each protocol on extravascular lung water and oxygenation changes in the post-operative periods, study the effect of each of the adopted method on postoperative complications, incidence of acute kidney injury and intensive care unit staying duration. Settings and Design: This study was a prospective randomized controlled clinical trial. Methods: The study was carried out on 60 patients scheduled for major abdominal surgery. 30 patients, whose intraoperative fluid administration was managed by stroke volume optimization, were compared with 30 patients who received intraoperative fluid therapy guided by stroke volume variation optimization. Results: There was no difference regarding haemodynamic changes in terms of mean heart rate, mean blood pressure, stroke volume, stroke volume variation, and cardiac index.