102 Clinical practice guideline. Integral Care Guidelines for the prevention, early detection and treatment of pregnancy, childbirth and puerperium complications: Section on toxoplasmosis in pregnancy Jorge Alberto Cortes a , *, Jorge Enrique Gómez b , Pedro Ignacio Silva c , Leonardo Arévalo d , Ingrid Arevalo Rodriguez e , Martha Isabel Álvarez f , Sandra Beltran g , Ivohne Fernanda Corrales h , Edith Angel Muller i ‘, German Ruiz j , Pio Ivan Gómez k , representing the Group that developed the Integral care pregnancy, childbirth and puerperium guidelines (CDG in Spanish) a Leader of the Toxoplasmosis Section in Pregnancy, Department of Internal Medicine and Research Group on Infectious Diseases, National University of Colombia, Bogotá. Colombia b GEPAMOL Group, Center for Biomedical Research, University of Quindío, Quindío, Colombia c Department of Gynecology, University of Santander, Santander, Colombia d Master in Sexual and Reproductive Health, El Bosque University, Bogota, Colombia e General Coordinator in Clinical Epidemiology, Integral Care Guidelines for Pregnancy, Childbirth and Puerperium, National University of Colombia, Bo- gota, Colombia f Pediatric Infectology Service, Fundación Cardioinfantil, Bogota, Colombia g Department of Pediatric Infectology, Sanitas International Organization; Co- lombian Association of Infectology, Bogota, Colombia Recibido: 5/02/2017; Aceptado: 5/02/2017 Cómo citar este artículo: Cortes JA, et al. Clinical practice guideline. Integral Care Guidelines for the prevention, early detection and treatment of preg- nancy, childbirth and puerperium complications: Section on toxoplasmosis in pregnancy. Infectio 2017. http://dx.doi.org/10.22354/in.v21i2.654 Abstract Toxoplasma infection, an aspect included in the Integral Care Guidelines for prevention, early detection and treatment of complications during pregnancy deve- loped and sponsored by the Department of Science, Technology and Innovation, Colciencias and the Ministry of Health and Social Protection; was selected to develop recommendations that may contribute to its prevention diagnostic and treatment. Guidelines were developed through systematic review of literature, two panels of evaluation, gradation of evidence: SIGN (Scottish Intercollegiate Guidelines Network), discussion panel with users and patients, external evaluation and socioeconomical evaluation of the impact of recommendations. The Toxoplasma gondii infection that occurs during pregnancy may cause serious complications for the fetus and important sequelae for the newborn. A clinical guideline based on the best available scientifc evidence, with emphasis on Colombian references, was performed. Experts in parasitology, neonatology and infectious diseases (adult and pediatric) developed the recommendations. It is suggested that the recom- mendations included in this guideline be followed by healthcare professionals in pregnancy care programs nationwide, with the purpose of lowering the morbidity and mortality related to this disease. Specifc recommendations for diagnosis during the frst trimester of the pregnancy, recommendations for prevention in non- infected women, identifcation of fetal or newborn infection and recommendations for treatment in those given cases are included. Guia de atencion integral para la prevencion, deteccion temprana y tratamiento de las complicaciones del embarazo: Sección de Toxoplasmosis Resumen Como parte de la Guia de atencion integral para la prevencion, deteccion temprana y tratamiento de las complicaciones del embarazo, desarrollada y fnanciada por el Departamento de Ciencia, Tecnologia e Innovacion, Colciencias, y el Ministerio de Salud y Proteccion Social de Colombia, se seleccionó a la infeccion por To- xoplasma para el desarrollo de recomendaciones para su prevencion, diagnostic° y tratamiento. La infeccion por Toxoplasma gondii (T. gondii) durante el embarazo puede resultar en graves complicaciones para el feto y dejar importantes secuelas al recien nacido. Se realizo una guia basada en la mejor evidencia disponible en ARTÍCULO ORIGINAL h Fundación Cardioinfantil, Bogotá, Colombia i Department of Gynecology and Obstetrics, National University of Colombia, Bogotá, Colombia J Maternity-Fetal Unit, Colombia University Clinic, Bogo- tá, Colombia k Professor and director of the Integral Care Guideline for Pregnancy, Child- birth and Puerperium; Leader of Research Group in Sexual and Reproduc- tive Health, Faculty of Medicine, National University of Colombia, Bogota, Colombia * Autor for correspondence Universidad Nacional de Colombia. Edifcio Facultad de Medicina. Departa- mento de Medicina Interna, Ofcina 510. Bogotá. Colombia. Tel. 31605000, ext. 15011. Fax: 3165000, ext. 15012. Correo electrónico: email: jacortesl@unaLedu.co (J.A. Cortes) This guide and its sections are part of a group of 25 Integral evidence-based integral care guidelines that include economic aspects and their implementa- tion within the context of the Colombian General Health Social Security System, that were developed by the Ministry of Health and Social Protection and the Department of Science, Technology and Innovation, Colciencias, so as to cover critical and high prevalence issues in the country The guideline was developed through contract awarded to the National University of Colombia in 2010.