CASE REPORT ABSTRACT Patients experiencing vasoplegia, a type of distributive shock, have limited options when conventional vasopressors are not appropriate or sufficient. This is especially true for patients with cardiac dysfunction, whether after heart transplant or ventricular assist device (VAD) implantation. Angiotensin II has been used in various clinical settings for distributive shock; however, its role in patients after orthotopic heart transplant or VAD implantation is not well studied. We present two cases where angiotensin II played a vital role in correcting vasoplegia for critical cardiac patients. CORRESPONDING AUTHOR: Amit Alam, MD Baylor University Medical Center, Dallas, Texas, US; Texas A&M University College of Medicine, Bryan, Texas, US amit.alam@bswhealth.org KEYWORDS: Angiotensin II; shock; heart failure; vasoplegia TO CITE THIS ARTICLE: Sovic W, Mathew C, Blough B, Monday K-A, Sam T, Zafar H, Guerrero-Miranda C, Sherwood M, Hebert C, Hall S, Alam A. Angiotensin II: A Multimodal Approach to Vasoplegia in a Cardiac Setting. Methodist DeBakey Cardiovasc J. 2021;17(4):98-101.doi: 10.14797/ mdcvj.576 WILLIAM SOVIC, MD CHRISTO MATHEW, MD BRITTON BLOUGH, MD KARA-ANN MONDAY, MD TEENA SAM, PHARMD HIRA ZAFAR, MBBS CESAR GUERRERO-MIRANDA, MD MELODY SHERWOOD, MD CHRISTOPHER HEBERT, MD SHELLEY HALL, MD AMIT ALAM, MD *Author affiliations can be found in the back matter of this article Angiotensin II: A Multimodal Approach to Vasoplegia in a Cardiac Setting