Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. Abstracts e1 Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved 11th INASH ABSTRACT BOOK 1 PREVALENCE AND POPULATION AT RISK FOR PERIPHERAL ARTERIAL DISEASE IN HYPERTENSIVE PATIENTS UNDERGOING HEMODIALYSIS Akhil Deepak Vatvani 1 , Vito A. Damay 2 , KaruniaValeriani Japar 1 , Kalis Waren 1 , Prio Wibisono 1 , Kusena 1 , Faridah Bunjamin 3 . 1 Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, 2 Department of Cardiovascular Medicine, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, 3 Lions Hemodialysis Clinic, Jakarta, Indonesia Background: Hypertensive patients with Chronic Kidney Disease are associated with cardiovascular disease. Peripheral Arterial Disease (PAD) is one of relatively underrated. The aim of this study is to identify the prevalence of PAD in hyper- tensive patients undergoing routine hemodialysis and its association with classic cardiovascular risk factors. Method: This is a multicenter cross sectional study that took place in 4 hemodialy- sis clinics in Jakarta from October to December 2016. We evaluated patients that have undergone hemodialysis for 6 months. PAD was diagnosed by Ankle Bra- chial Index (ABI). Patient was categorized as having PAD if ABI < 0.9. Hyperten- sion is defined as systolic BP 140 mmHg or diastolic BP 90 mmHg or taking antihypertensive medications. Analysis was done using Chi-square. Result: A total of 99 samples were collected, out of which 60 (60.6%) were male. The mean age of the patients were 52.7 (±12.6) years. There were 45 (45.5%) patients with PAD. PAD was significantly higher in patients aged >50 years (OR: 2.72, p: 0.025), male gender (OR: 2.75, p: 0.018), and in patients which had a his- tory of smoking (OR:2.89, p: 0.011). BMI, DM and alcohol history did not show any significant association with PAD. Conclusion: Almost half of the population in this study have abnormal ABI, which categorized them to have PAD. Age >50 years, male gender and positive smoking history are the factors that are associated with risk for PAD. DM as one of major risk factor of cardiovascular disease do not associate with PAD in this population, which assume that in hypertensive hemodialysis patients DM would not add any significant contribution in the presence of PAD. 2 HYPERTENSION IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS AT KARAWACI, TANGERANG, BANTEN, INDONESIA Andree Kurniawan, Nata Pratama Hadjo Lugito, Margaret Merlyn Tjiang, Stevent Sumantri, Aurea S. Soetjipto. Faculty of Medicine, University of Pelita Harapan, Tangerang, Banten, Indonesia Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune in- flammatory disease, usually affects women during their reproductive times. Risk for the development of cardiovascular disease is dramatically increased in SLE patients. Hypertension is a major risk factor for cardiovascular disease and the prevalent in women with SLE is still unknown especially in Asian patients. The aim of this study is to know the prevalence of hypertension in SLE patients and potential factors related. Method: This cross-sectional study evaluated SLE patients came to our Karawaci General hospital in period from 2013–2016. The diagnosis criteria of SLE was based on American Rheumatic Association (ARA) criteria. Hypertension diag- nosed if blood pressure >140/90 in three measurements in the one-week period. Kidney ultrasound was done to know if the patients had chronic kidney disease (CKD) and CKD patients were excluded. Status of inflammation were evaluated using high-sensitive C-reactive protein (Hs-CRP). Result: One hundred twenty-two SLE patients were included to this study, 94.3% patients were female, and median of age was 31.5 (12–77) years old. Hypertension were found in 18(14.8%) patients. Nephritic syndrome was diag- nosed in 67(54.9%) patients. Sixth nephritic patients had hypertension. Anti- Nuclear Antibody (ANA) was negative in 6(4.9%) patients. Fifteen (12.3%) patients had high Hs-CRP. High value of Hs-CRP did not correlate (p < 0.286) with occurrence of hypertension but the odds ratio (OR) was 2.495 (0.349– 17.81). Conclusion: Prevalence of hypertension in SLE patients was 14.8%. High Hs- CRP did not correlate to the occurrence of hypertension in SLE patients. 3 VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY VARIES BY AGE GROUPS A.A. Lukito 1,2 , A. Thengker 1 , M.W. Hadi 1 , A. Christiani 1 , V.A. Damay 1,2 , H. Lim 1,2 . 1 Siloam Hospitals Lippo Village, 2 Universitas Pelita Harapan, Indonesia Background: Aging and depressed spontaneous baroreceptor sensitivity (sBRS) and blood pressure variability (BPV) have been linked to negative cardiovascular outcomes. Visit-to-visit blood pressure (BP) variability is a predictor of an in- creased risk of all-cause mortality, stroke, left ventricular diastolic dysfunction, and cognitive impairment among diverse populations. However the relationship between BPV and age has not been clearly described by age groups. Method: Visit-to-visit BP data were collected from our institution’s medical re- cord department, which documented hypertensive patients in January-December 2015 who regularly attended follow-up visits. The BP data were tracking back until the first visit. The BPVs of these patients were calculated using standard deviation (SD) and average reading variability (AVR) in each follow up visit. AVR is defined as an average of absolute differences consecutive readings. Result: There were 131 subjects who met the inclusion criteria. There were 51.9% (68) male subjects with mean age of 58.61 (33–91 yo), 31% were 65 years or older and 15% were 75 years or older. The overall BPV data showed mean systolic BP (SBP)-AVR of 14.45 mmHg, mean diastolic BP (DBP)-AVR of 7.63 mmHg, mean SBP-SD of 15.36 mmHg and mean DBP-SD of 8.39 mmHg. Bivariate analysis using Pearson’s test showed statistically a significant negative correlation between DBP-AVR and age (p < 0.05, r: -0.20) and a negative correlation between DBP- SD and age (p < 0.05, r: -0.22). Moreover, in the age groups with cut-off 65 year- old, the mean SBP-ARV was 11.5 mmHg and mean DBP-ARV was 7.65 mmHg in 65 year-old and the mean SBP-ARV was 11.3 mmHg and mean DBP-ARV was 8.68 mmHg in < 65 year-old hypertensive subjects, while the mean SBP-SD was 11.9 mmHg and mean DBP-SD was 8.44 mmHg 65 year-old and the mean SBP-SD was 11.6 mmHg and mean DBP-SD was 9.18 mmHg in <65 year-old hypertensive subjects. While in the age groups with cut-off 75 year-old, the mean SBP-ARV was 11.6 mmHg and mean DBP-ARV was 7.77 mmHg in 75 year-old and, the mean SBP-ARV was 11.3 mmHg and mean DBP-ARV was 8.47 mmHg in <75 year-old hypertensive subjects, while the mean SBP-SD was 12.3 mmHg and mean DBP-SD was 8.69 mmHg 75 year-old and the mean SBP-SD was 11.6 mmHg and mean DBP-SD was 9.0 mmHg in <75 year-old hypertensive subjects. Data was analyzed with comparative independent-samples, and showed significant differences of DBP-ARV (p = 0.012) and DBP-SD (p = 0.02) in the age groups with cut-off 65 year-old, In contrary, there was significant difference of SBP-SD (p = 0.034) in the age groups with cut-off 75 year-old. Conclusion: This study found that ageing attenuated the diastolic blood pressure variability. In the age group subjects, diastolic BPV was lower in 65 year-old and systolic BPV was lower in 75 year-old hypertensive subjects. These findings confirmed the effect of ageing in the long-term visit-to-visit BPV. 8 A SCORING SYSTEM FOR DETECTING LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN HYPERTENSIVE PATIENTS Donny Setyawan Syamsul 1 , Nani Hersunarti 1 , Lies Dina Liastuti 1 , Aria Kekalih 2 , Rarsari Soerarso 1 , Bambang Budi Siswanto 1 . 1 Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardio- vascular Center Harapan Kita, Jakarta, Indonesia, 2 Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia Introduction: Hypertension is the most common condition seen in primary care and a risk factor for diastolic dysfunction. Diastolic dysfunction occurred before heart failure in hypertensive patients with preserved ejection fraction, therefore early diagnosis of diastolic dysfunction is very important. Several factors have been known to be associated with left ventricular diastolic dysfunction and a new scoring system could be generated from those factors. Methods: A cross sectional study was conducted in Tarakan General District Hospital North Kalimantan with hypertensive subjects on October 2016. Patients characteristics, all factors related to left ventricular diastolic dysfunction, and echocardiographic data were collected and analysed. Results : There were 132 total samples in this study, and left ventricular diastolic dysfunction was found in 40.2% samples. From logistic regression analysis, age 55 years old (p = 0.006), poor blood pressure control (p < 0.001), left ventricular